dc.creator | ANDRADE JÚNIOR, Dahir Ramos de | |
dc.creator | SANTOS, Sânia Alves dos | |
dc.creator | CASTRO, Isac de | |
dc.creator | ANDRADE, Dahir Ramos de | |
dc.date.accessioned | 2012-03-26T18:31:06Z | |
dc.date.accessioned | 2018-07-04T14:15:03Z | |
dc.date.available | 2012-03-26T18:31:06Z | |
dc.date.available | 2018-07-04T14:15:03Z | |
dc.date.created | 2012-03-26T18:31:06Z | |
dc.date.issued | 2008 | |
dc.identifier | The Brazilian Journal of Infectious Diseases, v.12, n.3, p.226-233, 2008 | |
dc.identifier | 1413-8670 | |
dc.identifier | http://producao.usp.br/handle/BDPI/9539 | |
dc.identifier | 10.1590/S1413-86702008000300013 | |
dc.identifier | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300013 | |
dc.identifier | http://www.scielo.br/pdf/bjid/v12n3/a13v12n3.pdf | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1607545 | |
dc.description.abstract | This study verified the correlation between the serum levels of TNF alpha and different clinical forms of tuberculosis. We described a group of 24 patients presenting several clinical forms of tuberculosis and a control group of 13 healthy individuals. The levels of TNF alpha were measured by bioassay method. The levels of TNF-alpha had significant differences between the tuberculosis and control groups. The patients with abnormal chest X-Ray findings had higher TNF alpha levels (15328.48 ± 4602.19 pg/mL) when compared to patients with normal X-Rays (3353.18 ± 1495.29 pg/mL) (p<0.05). Patients that lost weight had higher TNF alpha levels (15468.54 ± 4580.54 pg/mL) than those that didn't loose weight (2904.98 ± 1367.89) (p<0.05). The levels of TNF alpha were higher in patients with a positive PPD skin test than in those with a negative PPD test (p<0.05). There was a positive correlation between patients' clinical severity and the serum levels of TNF alpha. In patients with successive measurements of TNF alpha, we observed that there was a drop in cytokine levels, and also a clinical improvement concomitantly. We concluded that there was a correlation between serum TNF alpha levels and chest X-Ray alterations, loss of weight, positive PPD skin test and clinical severity in patients with tuberculosis. There was evidence of a worse clinical outcome in patients with tuberculosis that presented higher TNF alpha serum levels. | |
dc.language | eng | |
dc.publisher | Brazilian Society of Infectious Diseases | |
dc.relation | The Brazilian Journal of Infectious Diseases | |
dc.rights | Copyright Brazilian Society of Infectious Diseases | |
dc.rights | openAccess | |
dc.subject | TNF alpha | |
dc.subject | Tuberculosis | |
dc.subject | Cytokines | |
dc.subject | Clinical severity | |
dc.title | Correlation between serum tumor necrosis factor alpha levels and clinical severity of tuberculosis | |
dc.type | Artículos de revistas | |