dc.creator | LOUZADA-JÚNIOR, P. | |
dc.creator | FREITAS, M.V.C. | |
dc.creator | OLIVEIRA, R.D.R. | |
dc.creator | DEGHAIDE, N.H.S. | |
dc.creator | CONDE, R.A. | |
dc.creator | BERTOLO, M.B. | |
dc.creator | DONADI, E.A. | |
dc.date.accessioned | 2012-03-26T16:57:20Z | |
dc.date.accessioned | 2018-07-04T14:05:50Z | |
dc.date.available | 2012-03-26T16:57:20Z | |
dc.date.available | 2018-07-04T14:05:50Z | |
dc.date.created | 2012-03-26T16:57:20Z | |
dc.date.issued | 2008 | |
dc.identifier | Brazilian Journal of Medical and Biological Research, v.41, n.6, p.493-499, 2008 | |
dc.identifier | 0100-879X | |
dc.identifier | http://producao.usp.br/handle/BDPI/7461 | |
dc.identifier | 10.1590/S0100-879X2008005000021 | |
dc.identifier | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000600010 | |
dc.identifier | http://www.scielo.br/pdf/bjmbr/v41n6/7002.pdf | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1605831 | |
dc.description.abstract | The objective of the present study was to evaluate the contribution of the shared epitope (SE), the rheumatoid arthritis (RA) protection model, and the occurrence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in RA patients from a genetically diverse population. One hundred and forty Brazilian RA patients and 161 matched controls were typed for HLA-DRB1 alleles using amplified DNA hybridized with sequence-specific oligonucleotide probes or primers. Patients were stratified according to the presence or absence of SE (DRB1*0401, *0404, *0405, *0101, *1001, and *1402), of the DERAA alleles (DRB1*0103, *0402, *1102, *1103, *1301, *1302, and *1304), and X (all other alleles). Anti-CCP antibodies were measured by ELISA. The combined frequency of SE-positive alleles was significantly greater (76.4 vs 23.6%, P < 0.0001) than the controls. The SE/SE and SE/X genotypes were over-represented (P < 0.0001, OR = 6.02) and DERAA/X was under-represented in RA patients (P < 0.001, OR = 0.49), whereas the frequencies of the SE/DERAA, X/X and X/DERAA genotypes were not significantly different from controls. The frequency of anti-CCP antibodies was higher in SE-positive patients than in SE-negative patients (64.6 vs 44.7%, P = 0.03; OR = 2.25). Although the Brazilian population is highly miscegenated, the results of this study support the findings observed in most genetically homogeneous populations with RA; however, they are not mutually exclusive but rather complementary. The participation of DRB1-DERAA alleles in protection against RA was also observed (OR = 0.4; 95%CI = 0.23-0.68). | |
dc.language | eng | |
dc.publisher | Associação Brasileira de Divulgação Científica | |
dc.relation | Brazilian Journal of Medical and Biological Research | |
dc.rights | Copyright Associação Brasileira de Divulgação Científica | |
dc.rights | openAccess | |
dc.subject | Susceptibility to rheumatoid arthritis | |
dc.subject | HLA | |
dc.subject | Brazilians | |
dc.subject | Shared epitope | |
dc.subject | Anti-cyclic citrullinated peptide | |
dc.title | A majority of Brazilian patients with rheumatoid arthritis HLA-DRB1 alleles carry both the HLA-DRB1 shared epitope and anti-citrunillated peptide antibodies | |
dc.type | Artículos de revistas | |