dc.creator | AZEVEDO, Carolina H. M | |
dc.creator | WAJNGARTEN, Maurício | |
dc.creator | PRETE, Ana C. Lo | |
dc.creator | DIAMENT, Jayme | |
dc.creator | Maranhao, Raul Cavalcante | |
dc.date.accessioned | 2012-03-26T14:29:53Z | |
dc.date.accessioned | 2018-07-04T14:00:26Z | |
dc.date.available | 2012-03-26T14:29:53Z | |
dc.date.available | 2018-07-04T14:00:26Z | |
dc.date.created | 2012-03-26T14:29:53Z | |
dc.date.issued | 2011 | |
dc.identifier | Clinics, v.66, n.9, p.1543-1548, 2011 | |
dc.identifier | 1807-5932 | |
dc.identifier | http://producao.usp.br/handle/BDPI/6093 | |
dc.identifier | 10.1590/S1807-59322011000900006 | |
dc.identifier | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000900006 | |
dc.identifier | http://www.scielo.br/pdf/clin/v66n9/06.pdf | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1604621 | |
dc.description.abstract | OBJECTIVE: To verify whether the capacity of high-density lipoprotein (HDL) to simultaneously receive nonesterified cholesterol, triglycerides, cholesteryl esters, and phospholipids changes with aging and the presence of coronary artery disease. DESIGN: Cross-sectional study with biochemical analyses. SUBJECTS: Eleven elderly patients with coronary artery disease (74±5 years) were compared with the following groups of non-coronary artery disease subjects (referred to as "healthy"): 25 young (25±5 years), 25 middle-aged (42± years), and 25 elderly subjects (75±8 years). METHODS: Plasma samples were incubated with a nanoemulsion labeled with radioactive lipids; the transfer of the lipids from the nanoemulsion to the HDL was measured in chemically precipitated HDL. HDL size and paraoxonase-1 activity were also determined. RESULTS: The transfer of cholesteryl esters and phospholipids to high-density lipoprotein was significantly greater (p<0.001) in healthy elderly subjects than in the middle-aged and younger subjects. Non-esterified cholesterol and triglyceride transfer was not different among these three groups. The HDL size was significantly greater (p<0.001) in healthy elderly subjects than in the middle-aged and younger subjects. The paraoxonase-1 activity was similar among the groups. Compared with healthy elderly subjects, coronary artery disease elderly subjects had significantly less (p<0.05) transfer of non-esterified cholesterol, triglycerides, and cholesteryl esters to the HDL and a significantly smaller (p<0.05) HDL size. CONCLUSION: Because lipid transfer is enhanced in healthy elderly subjects but not in those with coronary artery disease, increasing lipid transfer to HDL may be a protective mechanism against the disease. | |
dc.language | eng | |
dc.publisher | Faculdade de Medicina / USP | |
dc.relation | Clinics | |
dc.rights | Copyright Faculdade de Medicina / USP | |
dc.rights | openAccess | |
dc.subject | Aging | |
dc.subject | Cholesteryl ester transfer protein (CETP) | |
dc.subject | Transfer proteins | |
dc.subject | Lipoproteins | |
dc.subject | Nanoparticles | |
dc.title | Simultaneous transfer of cholesterol, triglycerides, and phospholipids to high-density lipoprotein in aging subjects with or without coronary artery disease | |
dc.type | Artículos de revistas | |