dc.creator | ANDREAZZA, Itamar Francisco | |
dc.creator | FERRAZ, Humberto Gomes | |
dc.date.accessioned | 2012-03-26T14:28:49Z | |
dc.date.accessioned | 2018-07-04T14:00:16Z | |
dc.date.available | 2012-03-26T14:28:49Z | |
dc.date.available | 2018-07-04T14:00:16Z | |
dc.date.created | 2012-03-26T14:28:49Z | |
dc.date.issued | 2011 | |
dc.identifier | Brazilian Archives of Biology and Technology, v.54, n.2, p.315-320, 2011 | |
dc.identifier | 1516-8913 | |
dc.identifier | http://producao.usp.br/handle/BDPI/6052 | |
dc.identifier | 10.1590/S1516-89132011000200013 | |
dc.identifier | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000200013 | |
dc.identifier | http://www.scielo.br/pdf/babt/v54n2/v54n2a13.pdf | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1604581 | |
dc.description.abstract | The aim of this study was to prepare and evaluate the pellets, containing a highly soluble drug (ascorbic acid), by the extrusion-spheronization process and coated with a release controlling polymer. The coating (undertaken in a fluid bed) was applied to three batches of the pellets with a dispersion of Kollicoat® SR 30 D, with each batch of pellets receiving a different level of polymer (5.07; 8.26 and 10.35%). The coated pellets were evaluated for sphericity by imaging analysis and comparative dissolution profile with a product commercially available in Brazil. All of the evaluated samples presented adequate physical properties and the dissolution profile of those coated with 5.07% of polymer proved to be similar to that of the commercially available brand name. | |
dc.language | eng | |
dc.publisher | Tecpar | |
dc.relation | Brazilian Archives of Biology and Technology | |
dc.rights | Copyright Tecpar | |
dc.rights | openAccess | |
dc.subject | Coating | |
dc.subject | Pellets | |
dc.subject | Extrusion spheronization | |
dc.subject | Controlled release | |
dc.title | Preparation of pellets containing highly soluble drug by extrusion/spheronisation and coating with Kollicoat® SR 30D | |
dc.type | Artículos de revistas | |