dc.creatorANDREAZZA, Itamar Francisco
dc.creatorFERRAZ, Humberto Gomes
dc.date.accessioned2012-03-26T14:28:49Z
dc.date.accessioned2018-07-04T14:00:16Z
dc.date.available2012-03-26T14:28:49Z
dc.date.available2018-07-04T14:00:16Z
dc.date.created2012-03-26T14:28:49Z
dc.date.issued2011
dc.identifierBrazilian Archives of Biology and Technology, v.54, n.2, p.315-320, 2011
dc.identifier1516-8913
dc.identifierhttp://producao.usp.br/handle/BDPI/6052
dc.identifier10.1590/S1516-89132011000200013
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000200013
dc.identifierhttp://www.scielo.br/pdf/babt/v54n2/v54n2a13.pdf
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1604581
dc.description.abstractThe aim of this study was to prepare and evaluate the pellets, containing a highly soluble drug (ascorbic acid), by the extrusion-spheronization process and coated with a release controlling polymer. The coating (undertaken in a fluid bed) was applied to three batches of the pellets with a dispersion of Kollicoat® SR 30 D, with each batch of pellets receiving a different level of polymer (5.07; 8.26 and 10.35%). The coated pellets were evaluated for sphericity by imaging analysis and comparative dissolution profile with a product commercially available in Brazil. All of the evaluated samples presented adequate physical properties and the dissolution profile of those coated with 5.07% of polymer proved to be similar to that of the commercially available brand name.
dc.languageeng
dc.publisherTecpar
dc.relationBrazilian Archives of Biology and Technology
dc.rightsCopyright Tecpar
dc.rightsopenAccess
dc.subjectCoating
dc.subjectPellets
dc.subjectExtrusion spheronization
dc.subjectControlled release
dc.titlePreparation of pellets containing highly soluble drug by extrusion/spheronisation and coating with Kollicoat® SR 30D
dc.typeArtículos de revistas


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