To evaluate the hepatoprotective effect of Cucurbita maxima macre pumpkin in Rattus norvegicus treated with Isoniazid. Material and Methods: We worked with 30 rats, divided into 3 groups of 10 specimens each. They were administered for two weeks: Isoniazid 50mg/kg/d intraperitoneal administration to the control group G1, Silymarin 100mg/kg/d orally and Isoniazid 50mg/kg/d intraperitoneal administration to the experimental group G2, C. maximum 800 mg/kg/d orally and Isoniacida 50mg/kg/d intraperitoneal administration to the experimental group G3. A basal and final biochemical sample was determined. The specimens were sacrificed to perform the morphological analysis of the livers. Results: There is a hightly significant reduction of transaminases with the exception of total protein. The decrease is greater in G3 of Aspartate aminotransferase (63.7 ± 13.34 U/L) and Alanine aminotransferase (21.3 ± 2.58 U/L) (p<0.001). There is no significant difference in liver weight (p>0.05). There are very significant differences of the liver index in G1 and G3, being higher in G1 (09.03 ± 0.47%) (p<0.01). Conclusions: The administration of Cucurbita maxima (macre pumpkin) has a significant hepatoprotective effect in Rattus norvegicus treated with IsoniazidEvaluar el efecto hepatoprotector de la Cucurbita maxima (zapallo macre) en Rattus norvegicus tratadas con Isoniacida. Material y Métodos: Se trabajó con 30 ratas, divididas en 3 grupos de 10 especímenes cada uno. Se les administró durante dos semanas: Isoniacida 50mg/kg/d vía intraperitoneal al grupo control G1, Silimarina 100mg/kg/d vía oral e Isoniacida 50mg/kg/d vía intraperitoneal al grupo experimental G2, C. maxima 800 mg/kg/d vía oral e Isoniacida 50mg/kg/d vía intraperitoneal al grupo experimental G3. Se determinó una muestra bioquímica basal y final. Los especímenes fueron sacrificados para realizar el análisis morfológico de los hígados. Resultados: Existe reducción altamente significativa de transaminasas a excepción de proteínas totales. La disminución es mayor en G3 de Aspartato aminotransferasa (63.7 ± 13.34 U/L) y Alanino aminotransferasa (21.3 ± 2.58 U/L) (p<0.001). No existe diferencia significativa en peso hepático (p>0.05). Hay diferencia muy significativa del índice hepático en G1 y G3, siendo mayor en G1 (3.9 ± 0.47%) (p<0.01). Conclusión: La administración de Cucurbita maxima (variedad macre) presenta efecto hepatoprotector significativo en Rattus norvegicus tratadas con IsoniacidaTesis