| dc.contributor | Alva Plasencia, Pedro Marcelo | |
| dc.creator | Quijano Jara, Adimari Elisa | |
| dc.creator | Quipuscoa Lázaro, María Flor | |
| dc.date | 2016-11-15T14:13:20Z | |
| dc.date | 2016-11-15T14:13:20Z | |
| dc.date | 1/9/2010 | |
| dc.date.accessioned | 2018-04-27T14:16:13Z | |
| dc.date.available | 2018-04-27T14:16:13Z | |
| dc.identifier | http://dspace.unitru.edu.pe/handle/UNITRU/4789 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1427207 | |
| dc.description | The present study had a purpose evaluation dissolution profiles of propranolol 40mg tablets, multisource and innovative, with the object of establishing document evidence of “equivalence in vitro”. Was determined the amount of propranolol hydrochloride dissolved at 3, 6, 9, 12, 15, 20, 30, 45, 60, 90, 120min for both formulations in three media: 0.1 N HCl pH 1.2, Acetate Buffer phosphate buffer pH 4.5 and pH 6.8. Was determined the similarity factor f2 in the three media tested. The results obtained were f2 <50 for three media tested, The results of de analyses showed Propranolol 40 mg tablets, Multisource and Innovative are not bioequivalent in vitro. | |
| dc.description | El presente trabajo tubo como finalidad evaluar los perfiles de disolución de propranolol comprimidos 40mg, multifuente e innovador, con la finalidad de establecer una evidencia documentada de la “equivalencia in vitro”. Se determinó la cantidad de clorhidrato de propranolol disuelta a los 3, 6, 9, 12, 15, 20, 30, 45, 60, 90, 120min para ambas formulaciones en tres medios: HCl 0,1N pH 1,2; Buffer acetato pH 4,5 y Buffer fosfato pH 6,8.Se determinó el factor de similitud f2 en los tres medios ensayados. Se encontró que f2 < de 50, concluyéndose que las tabletas de Propranolol 40 mg Multifuente e Innovador no son bioequivalentes in vitro. | |
| dc.language | spa | |
| dc.publisher | Universidad Nacional de Trujillo | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/2.5/pe/ | |
| dc.source | Universidad Nacional de Trujillo | |
| dc.source | Repositorio Institucional - UNITRU | |
| dc.subject | Bioequivalencia | |
| dc.subject | Disolución | |
| dc.subject | Propranolol | |
| dc.subject | Inderal | |
| dc.title | Equivalencia de los perfiles de disolución de propranolol en comprimidos 40mg, multifuente e innovador” | |
| dc.type | Tesis | |
