Pioneering Ambient Mass Spectrometry Imaging In Psychiatry: Potential For New Insights Into Schizophrenia

dc.creatorVendramini
dc.creatorPedro H.; Gattaz
dc.creatorWagner F.; Schmitt
dc.creatorAndrea; Falkai
dc.creatorPeter; Eberlin
dc.creatorMarcos N.; Martins-de-Souza
dc.creatorDaniel
dc.date2016
dc.datenov
dc.date2017-11-13T13:58:09Z
dc.date2017-11-13T13:58:09Z
dc.date.accessioned2018-03-29T06:11:33Z
dc.date.available2018-03-29T06:11:33Z
dc.identifierSchizophrenia Research. Elsevier Science Bv, v. 177, p. 67 - 69, 2016.
dc.identifier0920-9964
dc.identifier1573-2509
dc.identifierWOS:000387963200010
dc.identifier10.1016/j.schres.2015.10.019
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0920996415300190?via%3Dihub
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/330207
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1367232
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionUnderstanding the molecular basis of schizophrenia is essential for disease management, and several molecular biology tools have been employed for this purpose. Mass spectrometry, which is used mostly in proteomic and metabolomic studies, is one such tool. Here, we present the first psychiatric study to use mass spectrometry imaging (MSI) with desorption electrospray ionization (DESI). Preparation of samples for use with DESI-MSI is remarkably simple and quick and preserves the spatial distribution of analytes. By using this tool, we found differences in the phospholipid content in schizophrenia postmortem brains. These results validate both the role of phospholipids in schizophrenia and the value of this MS tool in furthering the understanding of the molecular aspects of the disease. (C) 2015 Elsevier B.V. All rights reserved.
dc.description177
dc.description1-3
dc.description67
dc.description69
dc.descriptionFAPESP (Sao Paulo Research Foundation) [2013/08711-3, 2014/10068-4]
dc.descriptionCNPq (The Brazilian National Council for Scientific and Technological Development) [460289/2014-4]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageEnglish
dc.publisherElsevier Science BV
dc.publisherAmsterdam
dc.relationSchizophrenia Research
dc.rightsfechado
dc.sourceWOS
dc.subjectMass Spectrometry Imaging
dc.subjectProteomics
dc.subjectLipidomics
dc.subjectMetabolomics
dc.subjectMass Spectrometry
dc.subjectSchizophrenia
dc.subjectPostmortem Brains
dc.titlePioneering Ambient Mass Spectrometry Imaging In Psychiatry: Potential For New Insights Into Schizophrenia
dc.typeArtículos de revistas


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