Visfatin Is A Positive Predictor Of Bone Mineral Density In Young Survivors Of Acute Lymphocytic Leukemia

dc.creatorSiviero-Miachon
dc.creatorAdriana Aparecida; Spinola-Castro
dc.creatorAngela Maria; de Martino Lee
dc.creatorMaria Lucia; Calixto
dc.creatorAntonio Ramos; Geloneze
dc.creatorBruno; Lazaretti-Castro
dc.creatorMarise; Guerra-Junior
dc.creatorGil
dc.date2017
dc.datejan
dc.date2017-11-13T13:58:05Z
dc.date2017-11-13T13:58:05Z
dc.date.accessioned2018-03-29T06:11:30Z
dc.date.available2018-03-29T06:11:30Z
dc.identifierJournal Of Bone And Mineral Metabolism. Springer Japan Kk, v. 35, p. 73 - 82, 2017.
dc.identifier0914-8779
dc.identifier1435-5604
dc.identifierWOS:000394243900010
dc.identifier10.1007/s00774-015-0728-5
dc.identifierhttps://link.springer.com/article/10.1007%2Fs00774-015-0728-5
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/330194
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1367219
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionBone mass acquisition may be compromised in survivors of childhood acute lymphocytic leukemia due to various factors, including adiposity. Fat accumulation can affect bone through the direct effect of adipokines or indirectly through the state of chronic inflammation. The aim of this study was to evaluate the effect of body composition and adipokines on bone mass in survivors of acute lymphocytic leukemia. This was a cross-sectional study of 56 survivors aged between 15 and 24 years, 44.6 % of whom received cranial radiotherapy (18-24 Gy), assessed according to body fat, lean mass, and bone mineral density (dual energy X-ray absorptiometry), computed tomography scan-derived abdominal adipose tissue, and adipokines by a multiple regression analysis. Both lumbar spine L-1-L-4 (trabecular bone) and total body (cortical bone) bone mineral density were positively correlated with visfatin (p < 0.050). Lean mass index was positively correlated, while waist-to-height ratio was negatively correlated with cortical bone (p < 0.010). Low bone mineral density for chronological age was detected in 5.4 % of patients in total body, and 8.9 % at the lumbar spine. In survivors of acute lymphocytic leukemia, visfatin may play an important role in the complex relationship between body composition and bone. At present, visfatin may represent a model for further study of bone metabolism, and could possibly explain the unknown mechanisms linking bone metabolism and cancer.
dc.description35
dc.description1
dc.description73
dc.description82
dc.descriptionSao Paulo State Research Foundation [06/06162-9]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageEnglish
dc.publisherSpringer Japan KK
dc.publisherTokyo
dc.relationJournal of Bone and Mineral Metabolism
dc.rightsfechado
dc.sourceWOS
dc.subjectPrecursor Cell Lymphoblastic Leukemia-lymphoma/complications
dc.subjectBody Composition
dc.subjectMetabolic Syndrome X
dc.subjectAdipokines
dc.subjectBone Density
dc.titleVisfatin Is A Positive Predictor Of Bone Mineral Density In Young Survivors Of Acute Lymphocytic Leukemia
dc.typeArtículos de revistas


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