Incorporation And Release Kinetics Of Alpha-bisabolol From Pcl And Chitosan/guar Gum Membranes

dc.creatorBombaldi de Souza
dc.creatorF. C.; Bombaldi de Souza
dc.creatorR. F.; Moraes
dc.creatorA. M.
dc.date2016
dc.datejul-set
dc.date2017-11-13T13:57:50Z
dc.date2017-11-13T13:57:50Z
dc.date.accessioned2018-03-29T06:11:13Z
dc.date.available2018-03-29T06:11:13Z
dc.identifierBrasilian Journal Of Chemical Engineering. Brazilian Soc Chemical Eng , v. 33, p. 453 - 467, 2016.
dc.identifier0104-6632
dc.identifier1678-4383
dc.identifierWOS:000389234200004
dc.identifier10.1590/0104-6632.20160333s20150083
dc.identifierhttp://www.scielo.br/scielo.php?pid=S0104-66322016000300453&script=sci_arttext
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/330127
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1367152
dc.descriptionAlpha-bisabolol, an anti-inflammatory and antioxidant compound extracted from candeia trees (Eremanthus erythropappus), was incorporated into hydrophobic polycaprolactone (PCL) and hydrophilic chitosan/guar gum (Ch-G) membranes aiming at the production of bioactive wound dressings. The incorporation efficiency achieved a maximum of ca. 18% (1 gram of alpha-bisabolol per gram of membrane) for Ch-G membranes. For PCL membranes, all of the active compound added was retained (0.2 gram of alpha-bisabolol per gram of membrane). Alpha-bisabolol release in phosphate-buffered saline was relatively slow in both cases, reaching around 6% and 24% after 120 hours respectively for PCL and Ch-G membranes presenting equivalent initial alpha-bisabolol/membrane mass ratios. Both formulations were capable of releasing alpha-bisabolol in the typically recommended topical dose range (from 1 to 10 grams of alpha-bisabolol per gram of vehicle). The extended release periods observed are advantageous, allowing less frequent dressing changes and contributing to turn the treatment more comfortable for the patient.
dc.description33
dc.description3
dc.description453
dc.description467
dc.description20th Brazilian Congress of Chemical Engineering (COBEQ)
dc.descriptionOCT 19-22, 2014
dc.descriptionFlorianopolis, BRAZIL
dc.description
dc.languageEnglish
dc.publisherBrazilian Soc Chemical Eng
dc.publisherSão Paulo
dc.relationBrasilian Journal of Chemical Engineering
dc.rightsaberto
dc.sourceWOS
dc.subjectWound Dressing
dc.subjectMembrane
dc.subjectChitosan
dc.subjectGuar Gum
dc.subjectPolycaprolactone
dc.subjectAlpha - Bisabolol
dc.titleIncorporation And Release Kinetics Of Alpha-bisabolol From Pcl And Chitosan/guar Gum Membranes
dc.typeActas de congresos


Este ítem pertenece a la siguiente institución