Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Several factors can affect the magnitude of eccentric exercise (ECC)-induced muscle damage, but little is known regarding the effect of the range of motion (ROM) in ECC-induced muscle damage. The purpose of this study was to investigate whether elbow flexor ECC with 120 degrees of ROM (from 60 degrees of elbow flexion until elbow full extension - 180 degrees [120ROM]) induces a greater magnitude of muscle damage compared with a protocol with 60 degrees of ROM (120-180 degrees of elbow flexion [60ROM]). Twelve healthy young men (age: 22 +/- 3.1 years; height: 1.75 +/- 0.05 m; body mass: 75.6 +/- 13.6 kg) performed the ECC with 120ROM and 60ROM using different arms in a random order separated by 2 weeks and were tested before and 24, 48, 72 and 96 h after ECC for maximal voluntary isometric contraction torque (MVC-ISO), ROM and muscle soreness. The 120ROM protocol showed greater changes and effect sizes (ES) for MVC-ISO (-35%, ES: 1.97), ROM (-11.5 degrees, ES: 1.27) and muscle soreness (19 mm, ES: 1.18) compared with the 60ROM protocol (-23%, ES: 0.93; -12%, ES: 0.56; 17 degrees, ES: 0.63; 8 mm, ES: 1.07, respectively). In conclusion, ECC of the elbow flexors with 120 degrees of ROM promotes a greater magnitude of muscle damage compared with a protocol with 60 degrees of ROM, even when both protocols are performed at long muscle lengths.333285289Sao Paulo Research Foundation (FAPESP) [2013/21218-4, 2012/24499-1, 2014/19594-0, 2011/22122-5]National Council for Scientific and Technological Development (CNPq) grantFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)