Antiproliferative Activity Of Buttermilk Lipid Fractions Isolated Using Food Grade And Non-food Grade Solvents On Human Cancer Cell Lines

dc.creatorCastro-Gomez
dc.creatorPilar; Rodriguez-Alcala
dc.creatorLuis M.; Monteiro
dc.creatorKarin M.; Ruiz
dc.creatorAna L. T. G.; Carvalho
dc.creatorJoao E.; Fontecha
dc.creatorJavier
dc.date2016
dc.datedez
dc.date2017-11-13T13:56:37Z
dc.date2017-11-13T13:56:37Z
dc.date.accessioned2018-03-29T06:09:58Z
dc.date.available2018-03-29T06:09:58Z
dc.identifierFood Chemistry. Elsevier Sci Ltd, v. 212, p. 695 - 702, 2016.
dc.identifier0308-8146
dc.identifier1873-7072
dc.identifierWOS:000378757800088
dc.identifier10.1016/j.foodchem.2016.06.030
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0308814616309220?via%3Dihub
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/329903
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1366928
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionButtermilk is a dairy by-product with a high content of milk fat globule membranes (MFGMs), whose protein constituents are reported to be antiproliferative. Lipids represent about half of the composition of MFGM. The aim of this study was to isolate buttermilk lipid fractions and evaluate their potential antiproliferative effect. Selective extraction with food grade or non-food grade solvents was performed. Antiproliferative effectiveness of lipid extracts and their neutral and polar fractions was evaluated on nine human cancer cell lines. Fractions obtained using food grade ethanol gave a higher yield than those obtained using non-food grade solvents, and they effectively inhibited cell viability of the cancer cell lines investigated. These fractions, rich in phospho-and sphingolipids, were strongly antiproliferative against human ovary and colon cancer cells. This observation allowed us to hypothesize further analyses aimed at promoting the use of buttermilk polar lipid fractions as functional food additives. (C) 2016 Elsevier Ltd. All rights reserved.
dc.description212
dc.description695
dc.description702
dc.descriptionSpanish Ministry of Science and Innovation
dc.descriptionEuropean FEDER Funds [AGL 2011-26713, AGL 2014-56464]
dc.descriptionConselho Nacional de Desenvolvimento Cientifico e Tecnologico of Brazil
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageEnglish
dc.publisherElsevier Sci LTD
dc.publisherOxford
dc.relationFood Chemistry
dc.rightsfechado
dc.sourceWOS
dc.subjectButtermilk
dc.subjectPolar Lipids
dc.subjectPhospholipids
dc.subjectHuman Cancer Cells
dc.subjectFood Grade Solvent Extraction
dc.titleAntiproliferative Activity Of Buttermilk Lipid Fractions Isolated Using Food Grade And Non-food Grade Solvents On Human Cancer Cell Lines
dc.typeArtículos de revistas


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