Evaluation Of The Genotoxicity Of Euterpe Oleraceae Mart. (arecaceae) Fruit Oil (acai), In Mammalian Cells In Vivo

dc.creatorMarques
dc.creatorE. S.; Froder
dc.creatorJ. G.; Carvalho
dc.creatorJ. C. T.; Rosa
dc.creatorP. C. P.; Perazzo
dc.creatorF. F.; Maistro
dc.creatorE. L.
dc.date2016
dc.datejul
dc.date2017-11-13T13:56:01Z
dc.date2017-11-13T13:56:01Z
dc.date.accessioned2018-03-29T06:09:31Z
dc.date.available2018-03-29T06:09:31Z
dc.identifierFood And Chemical Toxicology. Pergamon-elsevier Science Ltd , v. 93, p. 13 - 19, 2016.
dc.identifier0278-6915
dc.identifier1873-6351
dc.identifierWOS:000378453900003
dc.identifier10.1016/j.fct.2016.04.018
dc.identifierhttp://www-sciencedirect-com.ez88.periodicos.capes.gov.br/science/article/pii/S0278691516301247?via%3Dihub
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/329793
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1366818
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionE. oleracea is a tropical plant from the Amazon region, with its fruit used for food, and traditionally, as an antioxidant, anti-inflammatory, hypocholesterolemic, for atherosclerotic disease, and has anticancer properties. The oil of the fruit has antidiarrheic, anti-inflammatory and antinociceptive activities, but without genotoxicity evaluation. Therefore, the aim of this study was to evaluate the genotoxic potential of E. oleracea fruit oil (EOO), in rat cells. Male Wistar rats were treated with EOO by gavage at doses of 30, 100 and 300 mg/kg, for 14 days, within a 24 h interval. The DNA damage in the leukocytes, liver, bone marrow and testicular cells, was assessed by the comet assay, and the clastogenic/aneugenic effects in the bone marrow cells, by the micronucleus test. Our phytochemicals characterization of the EOO showed the presence of vanillic, palmitic, gamma-linolenic, linoleic, oleic, cinnamic, caffeic, protocatechuic, ferulic, syringic acids, and flavonoids quercetin and kaempferol rutinoside as the main constituents. Both cytogenetic tests performed showed that EOO presented no significant genotoxic effects in the analyzed cells, at the three tested doses. These results indicate that, under our experimental conditions, E. oleracea fruit oil did not reveal genetic toxicity in rat cells. (C) 2016 Published by Elsevier Ltd.
dc.description93
dc.description13
dc.description19
dc.descriptionFAPESP-Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil [2012/17241-8]
dc.descriptionCAPES
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageEnglish
dc.publisherPergamon-Elsevier Science LTD
dc.publisherOxford
dc.relationFood and Chemical Toxicology
dc.rightsfechado
dc.sourceWOS
dc.subjectEuterpe Oleracea
dc.subjectArecaceae
dc.subjectAcai Oil
dc.subjectPhytochemical Of Acai
dc.subjectComet Assay
dc.subjectMicronucleus Test
dc.titleEvaluation Of The Genotoxicity Of Euterpe Oleraceae Mart. (arecaceae) Fruit Oil (acai), In Mammalian Cells In Vivo
dc.typeArtículos de revistas


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