Goniothalamin And Celecoxib Effects During Aging: Targeting Pro-inflammatory Mediators In Chemoprevention Of Prostatic Disorders

dc.creatorKido
dc.creatorLarissa Akemi; Montico
dc.creatorFabio; Vendramini-Costa
dc.creatorDebora Barbosa; Pilli
dc.creatorRonaldo Aloise; Alves Cagnon
dc.creatorValeria Helena
dc.date2017
dc.datejun
dc.date2017-11-13T13:55:51Z
dc.date2017-11-13T13:55:51Z
dc.date.accessioned2018-03-29T06:09:20Z
dc.date.available2018-03-29T06:09:20Z
dc.identifierProstate. Wiley-blackwell, v. 77, p. 838 - 848, 2017.
dc.identifier0270-4137
dc.identifier1097-0045
dc.identifierWOS:000399884100003
dc.identifier10.1002/pros.23324
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1002/pros.23324/full
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/329750
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1366775
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionProstate is highly affected by aging, which lead to inflammatory disorders that can predispose to cancer development. Chemoprevention has emerged as a new therapeutic approach, intensifying studies evaluating the biological properties of new compounds. The aim of this study was to characterize the inflammatory responses in the prostate ventral lobe from senile mice treated with Goniothalamin (GTN), a promising natural compound with anti-inflammatory and antiproliferative properties. Its activity was compared to Celecoxib, an established nonsteroidal anti-inflammatory drug (NSAID). METHODSThe animals were divided into: Control groups; Young (18-week-old FVB), Senile (52-week-old FVB). Treated groups: Senile-Goniothalamin (150mg/kg orally), Senile-Celecoxib (10mg/kg orally). The ventral lobe was collected after 4 weeks for light microscopy, immunohistochemistry, ELISA, and Western blotting analysis. RESULTSBoth treatments were efficient in controlling the inflammatory process in the prostate from senile mice, maintaining the glandular morphology integrity. GTN reduced all inflammatory mediators evaluated (TNF-, COX-2, iNOS) and different from Celecoxib, it also decreased the protein levels of NF-kB and p-NF-kB. CONCLUSIONSFinally, GTN and Celecoxib controlled inflammation in the prostate, and sensitized the senescent microenvironment to anti-inflammatory stimuli. Thus, both treatments are indicated as potential drugs in the prostatic diseases prevention during senescence. (c) 2017 Wiley Periodicals, Inc.
dc.description77
dc.description8
dc.description838
dc.description848
dc.descriptionFAPESP [2013/01294-8, 2013/23049-5]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageEnglish
dc.publisherWiley-Blackwell
dc.publisherHoboken
dc.relationProstate
dc.rightsfechado
dc.sourceWOS
dc.subjectProstate
dc.subjectAging
dc.subjectInflammation
dc.subjectGoniothalamin
dc.subjectCelecoxib
dc.titleGoniothalamin And Celecoxib Effects During Aging: Targeting Pro-inflammatory Mediators In Chemoprevention Of Prostatic Disorders
dc.typeArtículos de revistas


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