Anti-inflammatory Effects Of Enemas Containing An Oily Extract Of Curcumin In An Experimental Model Of Diversion Colitis

dc.creatorKadri
dc.creatorCaled Jaoudat; Pereira
dc.creatorJose Aires; Campos
dc.creatorFabio Guilherme; Ortega
dc.creatorManoela Marques; Bragion
dc.creatorCelene Benediti; Real Martinez
dc.creatorCarlos Augusto
dc.date2017
dc.datefev
dc.date2017-11-13T13:55:19Z
dc.date2017-11-13T13:55:19Z
dc.date.accessioned2018-03-29T06:08:46Z
dc.date.available2018-03-29T06:08:46Z
dc.identifierHistology And Histopathology . F Hernandez , v. 32, p. 161 - 169, 2017.
dc.identifier0213-3911
dc.identifier1699-5848
dc.identifierWOS:000390219500007
dc.identifier10.14670/HH-11-783
dc.identifierhttp://www.hh.um.es/Abstracts/Vol_32/32_2/32_2_161.htm
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/329619
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1366644
dc.descriptionCurcumin has powerful anti-inflammatory and antioxidant effects and it has been used for treatment of distal ulcerative colitis. The therapeutic effects of curcumin have not yet been evaluated in diversion colitis. The aim of the present study was to evaluate the anti-inflammatory effects of curcumin on colonic mucosa devoid of a faecal stream. Thirty-six rats were subjected to a proximal colostomy and distal colonic fistulation. They were divided into two groups, which were sacrificed two or four weeks after the intervention. Each group was divided into three subgroups treated with the daily application of enemas containing saline or an oily extract of curcumin at 50 mg/kg/day or 200 mg/kg/day. Colitis was diagnosed by histological analysis. Inflammatory grades were assessed using a previously validated scoring system. The infiltration of neutrophils was evaluated based on the tissue expression of myeloperoxidase (MPO), as determined by immunohistochemistry, and a computer-assisted image analysis program. The Mann-Whitney test was used to compare inflammation grades and myeloperoxidase levels among groups, and ANOVA was used to verify the variance over time, with the level of significance set at 5% (p<0.05) for both tests. Enemas containing curcumin improved the inflammation of the mucosa without a faecal stream and reduced the tissue contents of MPO. MPO tissue levels did not vary with time or between the concentrations of curcumin used. Enemas with curcumin improved the inflammation of the colonic mucosa, reduced the inflammatory grade and decreased the tissue content of MPO in colon segments without a faecal stream.
dc.description32
dc.description2
dc.description161
dc.description169
dc.languageEnglish
dc.publisherF Hernandez
dc.publisherMurcia
dc.relationHistology and Histopathology
dc.rightsaberto
dc.sourceWOS
dc.subjectColitis
dc.subjectFatty Acids
dc.subjectVolatile
dc.subjectCurcumin
dc.subjectImage Processing
dc.subjectComputer-assisted
dc.titleAnti-inflammatory Effects Of Enemas Containing An Oily Extract Of Curcumin In An Experimental Model Of Diversion Colitis
dc.typeArtículos de revistas


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