Association Between Polymorphisms In Genes Related To Dna Base-excision Repair With Risk And Prognosis Of Oropharyngeal Squamous Cell Carcinoma

dc.creatorDias Costa
dc.creatorEricka Francislaine; Santos
dc.creatorErika Stocco; Liutti
dc.creatorVitor Teixeira; Leal
dc.creatorFrederico; Antunes Santos
dc.creatorVivian Castro; Rinck-Junior
dc.creatorJose Augusto; Viviane Mariano
dc.creatorFernanda; Malheiros Coutinho-Camillo
dc.creatorClaudia; Altemani
dc.creatorAlbina; Passos Lima
dc.creatorCarmen Silvia; Lourenco
dc.creatorGustavo Jacob
dc.date2016
dc.dateset
dc.date2017-11-13T13:55:02Z
dc.date2017-11-13T13:55:02Z
dc.date.accessioned2018-03-29T06:08:31Z
dc.date.available2018-03-29T06:08:31Z
dc.identifierJournal Of Cancer Research And Clinical Oncology . Springer , v. 142, p. 1917 - 1926, 2016.
dc.identifier0171-5216
dc.identifier1432-1335
dc.identifierWOS:000382151600005
dc.identifier10.1007/s00432-016-2202-8
dc.identifierhttps://link-springer-com.ez88.periodicos.capes.gov.br/article/10.1007%2Fs00432-016-2202-8
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/329558
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1366583
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionWe examined the influence of OGG1 c.977C > G (rs1052133), APEX1 c.444T > G (rs1130409), XRCC1 c.-77T > C (rs3213245), c.580C > T (rs1799782), c.839G > A (rs25489) and c.1196G > A (rs25487) single-nucleotide polymorphisms (SNPs), involved in base-excision repair (BER) pathway, on oropharyngeal squamous cell carcinoma (OPSCC) risk and prognosis. Aiming to identify the genotypes, DNA from 200 consecutive OPSCC patients and 200 controls was analyzed by PCR-RFLP. The prognostic impact of genotypes of SNPs on progression-free survival (PFS) and overall survival of OPSCC patients was examined using the Kaplan-Meier estimates and Cox regression analyses. XRCC1 c.580CT or TT genotypes (19.5 vs. 11.0 %, P = 0.04) and XRCC1 TTGG haplotype from c.-77T > C, c.580C > T, c.839G > A and c.1196G > A SNPs (17.5 vs. 10.0 %, P = 0.04) were more common in patients with OPSCC than in controls. Carriers of combined genotypes of c.580C > T and TTGG haplotype of XRCC1 gene were under 3.35- and 3.22-fold increased risk of OPSCC than others. For survival analysis, we selected only patients with tumor at stage IV. The median follow-up time was 24.5 months. At 24 months of follow-up, PFS was shorter in patients with OGG1 c.977CC genotype when compared with others genotypes (35.5 vs. 52.1 %, log-rank test, P = 0.03). After multivariate Cox analysis, patients with OGG1 c.977CC genotype had more chance to present tumor progression when compared with others (HR 1.68, P = 0.02). Our data present, for the first time, evidence that inherited OGG1 c.977C > G; XRCC1 c.-77T > C, c.580C > T, c.839G > A and c.1196G > A abnormalities of DNA BER pathway are important determinants of OPSCC and predictors of patient outcomes.
dc.description142
dc.description9
dc.description1917
dc.description1926
dc.descriptionSao Paulo Research Foundation (FAPESP) [2012/18623-1]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageEnglish
dc.publisherSpringer
dc.publisherNew York
dc.relationJournal of Cancer Research and Clinical Oncology
dc.rightsfechado
dc.sourceWOS
dc.subjectOropharyngeal Squamous Cell Carcinoma
dc.subjectBase-excision Repair Pathway
dc.subjectPolymorphisms
dc.subjectRisk
dc.subjectPrognosis
dc.titleAssociation Between Polymorphisms In Genes Related To Dna Base-excision Repair With Risk And Prognosis Of Oropharyngeal Squamous Cell Carcinoma
dc.typeArtículos de revistas


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