Changes In The Inner Ear Structures In Cystic Fibrosis Patients

dc.creatorPauna
dc.creatorHenrique F.; Monsanto
dc.creatorRafael C.; Kurata
dc.creatorNatsuko; Paparella
dc.creatorMichael M.; Cureoglu
dc.creatorSebahattin
dc.date2017
dc.datejan
dc.date2017-11-13T13:54:44Z
dc.date2017-11-13T13:54:44Z
dc.date.accessioned2018-03-29T06:08:12Z
dc.date.available2018-03-29T06:08:12Z
dc.identifierInternational Journal Of Pediatric Otorhinolaryngology. Elsevier Ireland Ltd, v. 92, p. 108 - 114, 2017.
dc.identifier0165-5876
dc.identifier1872-8464
dc.identifierWOS:000393245100021
dc.identifier10.1016/j.ijporl.2016.11.013
dc.identifierhttp://www.ijporlonline.com/article/S0165-5876(16)30411-6/abstract
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/329485
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1366510
dc.descriptionAlthough prolonged use of antibiotics is very common in cystic fibrosis (CF) patients, no studies have assessed the changes in both cochlear and peripheral vestibular systems in this population. Methods: We used human temporal bones to analyze the density of vestibular dark, transitional, and hair cells in specimens from CF patients who were exposed to several types of antibiotics, as compared with specimens from an age-matched control group with no history of ear disease or antibiotic use. Additionally, we analyzed the changes in the elements of the cochlea (hair cells, spiral ganglion neurons, and the area of the stria vascularis). Data was gathered using differential interference contrast microscopy and light microscopy. Results: In the CF group, 83% of patients were exposed to some ototoxic drugs, such as aminoglycosides. As compared with the control group, the density of both type I and type II vestibular hair cells was significantly lower in all structures analyzed; the number of dark cells was significantly lower in the lateral and posterior semicircular canals. We noted a trend toward a lower number of both inner and outer cochlear hair cells at all turns of the cochlea. The number of spiral ganglion neurons in Rosenthal's canal at the apical turn of the cochlea was significantly lower; furthermore, the area of the stria vascularis at the apical turn of the cochlea was significantly smaller. Conclusions: Deterioration of cochlear and vestibular structures in CF patients might be related to their exposure to ototoxic antibiotics. Well-designed case-control studies are necessary to rule out the effect of CF itself. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
dc.description92
dc.description108
dc.description114
dc.descriptionNational Institute of Health's National Institute on Deafness and Other Communication Disorders (NIDCD) [U24 DC01 1968-01]
dc.descriptionInternational Hearing Foundation
dc.descriptionStarkey Hearing Foundation
dc.descriptionLions 5M International
dc.languageEnglish
dc.publisherElsevier Ireland LTD
dc.publisherClare
dc.relationInternational Journal of Pediatric Otorhinolaryngology
dc.rightsfechado
dc.sourceWOS
dc.subjectCystic Fibrosis
dc.subjectInner Ear Changes
dc.subjectAntibiotics
dc.subjectVestibular Cells
dc.subjectCochlear Cells
dc.titleChanges In The Inner Ear Structures In Cystic Fibrosis Patients
dc.typeArtículos de revistas


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