Ultrasound-promoted Synthesis Of 3-(thiophen-2-yl)-4,5-dihydro-1h-pyrazole-1carboximidamides And Anticancer Activity Evaluation In Leukemia Cell Lines

dc.creatordos Santos
dc.creatorEric F. S.; Cury
dc.creatorNathalia M.; do Nascimento
dc.creatorTainara A.; Raminelli
dc.creatorCristiano; Casagrande
dc.creatorGleison A.; Pereira
dc.creatorClaudio M. P.; Simionatto
dc.creatorEuclesio; Yunes
dc.creatorJose A.; Pizzuti
dc.creatorLucas
dc.date2017
dc.datefev
dc.date2017-11-13T13:54:30Z
dc.date2017-11-13T13:54:30Z
dc.date.accessioned2018-03-29T06:07:53Z
dc.date.available2018-03-29T06:07:53Z
dc.identifierJournal Of The Brazilian Chemical Society. Soc Brasileira Quimica, v. 28, p. 217 - 224, 2017.
dc.identifier0103-5053
dc.identifier1678-4790
dc.identifierWOS:000394031600003
dc.identifier10.5935/0103-5053.20160166
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50532017000200217&lng=en&nrm=iso&tlng=en
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/329412
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1366437
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboximidamides were efficiently prepared through a cyclocondensation of thiophenylchalcones with aminoguanidine hydrochloride under ultrasonic conditions in the presence of KOH and ethanol as a green solvent in short reaction times (15-35 min) and good yields (62-95%). All compounds produced were evaluated against the human Jurkat and RS4; 11 acute lymphoblastic leukemia cell lines of T- and B-cell origin, respectively, and the K562 myelogenous leukemia cell line. Six compounds presented half maximal inhibitory concentration (IC50) values around 15 mu mol L-1 and five compounds presented IC50 values around 40 mu mol L-1 for at least one of the three cell lines analyzed. One compound was not significantly cytotoxic, presenting IC50 value > 100 mu mol L- 1.
dc.description28
dc.description2
dc.description217
dc.description224
dc.descriptionConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [483021/2013-0]
dc.descriptionFundacao de Apoio ao Desenvolvimento do Ensino, Ciencia e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT) [0180/12]
dc.descriptionFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [12/12802-1]
dc.descriptionCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.descriptionFAPESP
dc.descriptionCNPq
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageEnglish
dc.publisherSoc Brasileira Quimica
dc.publisherSão Paulo
dc.relationJournal of the Brazilian Chemical Society
dc.rightsaberto
dc.sourceWOS
dc.subjectAmidinopyrazole
dc.subjectPyrazoline
dc.subjectCytotoxic Activity
dc.subjectLeukemia
dc.subjectUltrasonic Irradiation
dc.titleUltrasound-promoted Synthesis Of 3-(thiophen-2-yl)-4,5-dihydro-1h-pyrazole-1carboximidamides And Anticancer Activity Evaluation In Leukemia Cell Lines
dc.typeArtículos de revistas


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