Significant Role Of Collagen Xvii And Integrin Beta 4 In Migration And Invasion Of The Less Aggressive Squamous Cell Carcinoma Cells

dc.creatorMoilanen
dc.creatorJyri M.; Loeffek
dc.creatorStefanie; Kokkonen
dc.creatorNina; Salo
dc.creatorSirpa; Vayrynen
dc.creatorJuha P.; Hurskainen
dc.creatorTiina; Manninen
dc.creatorAki; Riihila
dc.creatorPilvi; Heljasvaara
dc.creatorRitva; Franzke
dc.creatorClaus-Werner; Kahari
dc.creatorVeli-Matti; Salo
dc.creatorTuula; Makinen
dc.creatorMarkus J.; Tasanen
dc.creatorKaisa
dc.date2017
dc.datemar
dc.date2017-11-13T13:44:14Z
dc.date2017-11-13T13:44:14Z
dc.date.accessioned2018-03-29T05:58:51Z
dc.date.available2018-03-29T05:58:51Z
dc.identifierScientific Reports. Nature Publishing Group, v. 7, p. , 2017.
dc.identifier2045-2322
dc.identifierWOS:000397042300001
dc.identifier10.1038/srep45057
dc.identifierhttp://www-nature.ez88.periodicos.capes.gov.br/articles/srep45057
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/328713
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1365738
dc.descriptionCollagen XVII and integrin alpha 6 beta 4 have well-established roles as epithelial adhesion molecules. Their binding partner laminin 332 as well as integrin alpha 6 beta 4 are largely recognized to promote invasion and metastasis in various cancers, and collagen XVII is essential for the survival of colon and lung cancer stem cells. We have studied the expression of laminin.2, collagen XVII and integrin beta 4 in tissue microarray samples of squamous cell carcinoma (SCC) and its precursors, actinic keratosis and Bowen's disease. The expression of laminin.2 was highest in SCC samples, whereas the expression of collagen XVII and integrin beta 4 varied greatly in SCC and its precursors. Collagen XVII and integrin beta 4 were also expressed in SCC cell lines. Virus-mediated RNAi knockdown of collagen XVII and integrin beta 4 reduced the migration of less aggressive SCC-25 cells in horizontal scratch wound healing assay. Additionally, in a 3D organotypic myoma invasion assay the loss of collagen XVII or integrin beta 4 suppressed equally the migration and invasion of SCC-25 cells whereas there was no effect on the most aggressive HSC-3 cells. Variable expression patterns and results in migration and invasion assays suggest that collagen XVII and integrin beta 4 contribute to SCC tumorigenesis.
dc.description7
dc.descriptionAcademy of Finland
dc.descriptionOulu University Hospital
dc.descriptionNorthern Finland Cancer Association
dc.descriptionTurku University Hospital [13336]
dc.descriptionSigrid Juselius Foundation
dc.descriptionCancer Research Foundation of Finland
dc.languageEnglish
dc.publisherNature Publishing Group
dc.publisherLondon
dc.relationScientific Reports
dc.rightsaberto
dc.sourceWOS
dc.subjectAlpha-6-beta-4 Integrin
dc.subjectTumor Microenvironment
dc.subjectColorectal-cancer
dc.subjectRna Interference
dc.subjectExpression
dc.subjectSkin
dc.subjectKeratinocytes
dc.subjectMetastasis
dc.subjectGrowth
dc.subjectProgression
dc.titleSignificant Role Of Collagen Xvii And Integrin Beta 4 In Migration And Invasion Of The Less Aggressive Squamous Cell Carcinoma Cells
dc.typeArtículos de revistas


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