Design And Synthesis Of Cenocladamide Analogues And Their Evaluation Against Breast Cancer Cell Lines

dc.creatorSantos
dc.creatorCarla C. F.; Paradela
dc.creatorLuciana S.; Novaes
dc.creatorLuiz F. T.; Dias
dc.creatorSandra M. G.; Pastre
dc.creatorJulio C.
dc.date2017
dc.dateabr
dc.date2017-11-13T13:43:54Z
dc.date2017-11-13T13:43:54Z
dc.date.accessioned2018-03-29T05:58:37Z
dc.date.available2018-03-29T05:58:37Z
dc.identifierMedchemcomm. Royal Soc Chemistry, v. 8, p. 755 - 766, 2017.
dc.identifier2040-2503
dc.identifier2040-2511
dc.identifierWOS:000399918800007
dc.identifier10.1039/c6md00577b
dc.identifierhttp://pubs.rsc.org/is/content/articlelanding/2016/md/c6md00577b#!divAbstract
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/328661
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1365686
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThis work describes the total synthesis of the alkaloid cenocladamide and a concise library of nine structural analogues aiming at their evaluation against the breast cancer cell line MDA-MB-231. The most promising compound (3; IC50 = 6.6 mu M) was also evaluated in a panel of seven breast cancer cell lines and two non-tumorigenic cell lines. We further conducted an initial investigation on the mechanism of action of analogue 3, which lacks the endocyclic double bond when compared to cenocladamide. The present study presents the discovery of a cenocladamide analogue with interesting cytotoxic activity, which could be useful for further optimization towards new chemotherapeutic agents for breast cancer treatment.
dc.description8
dc.description4
dc.description755
dc.description766
dc.descriptionSao Paulo Research Foundation (FAPESP) [2014/26378-2, 2014/25770-6, 2014/15968-3, 2015/08199-6]
dc.descriptionCNPq [453862/2014-4]
dc.descriptionFAEPEX-UNICAMP [0877/14]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageEnglish
dc.publisherRoyal Soc Chemistry
dc.publisherCambridge
dc.relationMedChemComm
dc.rightsfechado
dc.sourceWOS
dc.subjectNatural-products
dc.subjectIn-vitro
dc.subjectSpecialist Herbivores
dc.subjectAza-goniothalamin
dc.subjectPiper-cenocladum
dc.subjectHeterogeneity
dc.subjectGeneralist
dc.subjectMetastasis
dc.subjectMechanisms
dc.subjectDiscovery
dc.titleDesign And Synthesis Of Cenocladamide Analogues And Their Evaluation Against Breast Cancer Cell Lines
dc.typeArtículos de revistas


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