Adverse Drug Reactions And Kinetics Of Cisplatin Excretion In Urine Of Patients Undergoing Cisplatin Chemotherapy And Radiotherapy For Head And Neck Cancer: A Prospective Study

dc.creatorVisacri
dc.creatorMarilia Berlofa; Pincinato
dc.creatorEder de Carvalho; Ferrari
dc.creatorGraziele Baldan; Franca Quintanilha
dc.creatorJulia Coelho; Mazzola
dc.creatorPriscila Gava; Passos Lima
dc.creatorCarmen Silvia; Moriel
dc.creatorPatricia
dc.date2017
dc.dateabr
dc.date2017-11-13T13:43:51Z
dc.date2017-11-13T13:43:51Z
dc.date.accessioned2018-03-29T05:58:35Z
dc.date.available2018-03-29T05:58:35Z
dc.identifierDaru-journal Of Pharmaceutical Sciences. Biomed Central Ltd, v. 25, p. , 2017.
dc.identifier2008-2231
dc.identifierWOS:000400325500001
dc.identifier10.1186/s40199-017-0178-9
dc.identifierhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404337/
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/328655
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1365680
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionCisplatin is a high-potency anticancer agent; however, it causes significant adverse drug reactions (ADRs). Potential pharmacokinetic markers must be studied to predict or prevent cisplatin-induced ADRs and achieve better prognosis. This study was designed to investigate the relationship between ADRs and kinetics of cisplatin excretion in the urine of patients undergoing high-dose cisplatin chemotherapy and radiotherapy for head and neck cancer. Methods: Outpatients with head and neck cancer received a first cycle of high-dose cisplatin chemotherapy (80-100 mg/m(2)) concurrent to radiotherapy. ADRs (haematological, renal, and gastrointestinal reactions) were classified based on severity by National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE, version 4, grade 0-4). The kinetics of cisplatin excretion in urine was evaluated by high-performance liquid chromatography over three time periods: 0-12, 12-24, and 24-48 h after the administration of cisplatin. Spearman Correlation test and regression analysis were performed to assess the relationship between ADRs and cisplatin excretion in the urine. Results: In total, 59 patients with a mean age of 55.6 +/- 9.4 years were analysed; most patients were male (86.4%), white (79.7%), and with pharyngeal tumours in advanced stages (66.1%). The most frequently observed ADRs were anaemia (81.4%), lymphopenia (78%), and nausea (64.4%); mostly grades 1 and 2 of toxicity. The mean cisplatin excretion was 70.3 +/- 64.4, 7.3 +/- 6.3, and 5 +/- 4 mu g/mg creatinine at 0-12, 12-24, and 24-48 h, respectively. Statistical analysis showed that the amount of cisplatin excreted did not influence the severity of ADRs. Conclusions: The most frequent ADRs were anaemia, lymphopenia, and nausea. Grades 1 and 2 were the severities for most ADRs. The period over which the highest cisplatin excretion observed was 0-12 h after chemotherapy, and cisplatin excretion could not predict toxicity.
dc.description25
dc.descriptionSao Paulo Research Foundation (FAPESP) [2012/01807-2, 2014/18294-3, 2014/04744-7]
dc.descriptionCoordination for the Improvement of Higher Level Personnel (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageEnglish
dc.publisherBiomed Central Ltd
dc.publisherLondon
dc.relationDARU-Journal of Pharmaceutical Sciences
dc.rightsaberto
dc.sourceWOS
dc.subjectAdverse Drug Reaction
dc.subjectExcretion
dc.subjectUrine
dc.subjectCisplatin
dc.subjectChemotherapy
dc.subjectHead And Neck Cancer
dc.titleAdverse Drug Reactions And Kinetics Of Cisplatin Excretion In Urine Of Patients Undergoing Cisplatin Chemotherapy And Radiotherapy For Head And Neck Cancer: A Prospective Study
dc.typeArtículos de revistas


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