dc.creator | Pelegrini | |
dc.creator | Marina Dal'Bo; Pereira | |
dc.creator | Juliana Biar; Costa | |
dc.creator | Solange dos Santos; Salazar Terreros | |
dc.creator | Myriam Janeth; Degrossoli | |
dc.creator | Adriana; Giorgio | |
dc.creator | Selma | |
dc.date | 2016 | |
dc.date | jul | |
dc.date | 2017-11-13T13:43:50Z | |
dc.date | 2017-11-13T13:43:50Z | |
dc.date.accessioned | 2018-03-29T05:58:34Z | |
dc.date.available | 2018-03-29T05:58:34Z | |
dc.identifier | Asian Pacific Journal Of Tropical Medicine. Elsevier Sci Ltd, v. 9, p. 633 - 638, 2016. | |
dc.identifier | 1995-7645 | |
dc.identifier | WOS:000378577500006 | |
dc.identifier | 10.1016/j.apjtm.2016.05.018 | |
dc.identifier | http://www.sciencedirect.com/science/article/pii/S1995764516301079 | |
dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/328651 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1365676 | |
dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description | To evaluate whether hypoxia inducible factor (HIF-1 alpha) targeting pharmacological drugs, echinomycin, resveratrol and CdCl2, which inhibit HIF-1 alpha stimulation, and mimosine, which enhances the stability of HIF-1 alpha present antileishmanial properties. Methods: The leishmanicidal effect of drugs was evaluated in mouse macrophages and Balb/c mouse model for cutaneous leishmaniosis. Results: Resveratrol and CdCl2, reduced the parasite load [IC50, (27.3 +/- 2.25) mu M and (24.8 +/- 0.95) mu M, respectively]. The IC50 value of echinomycin was (22.7 +/- 7.36) mu M and mimosine did not alter the parasite load in primary macrophages. The macrophage viability IC50 values for resveratrol, echinomycin and CdCl2, and mimosine were >40 mu M, >100 mu M > 200 mu M and>2 000 mu M, respectively. In vivo no differences between cutaneous lesions from control, resveratrol- and echinomycin-treated Balb/c mice were detected. Conclusions: Resveratrol, echinomycin and CdCl2, reduce parasite survival in vitro. The HIF-1 alpha targeting pharmacological drugs require further study to more fully determine their anti-Leishmania potential and their role in therapeutic strategies. | |
dc.description | 9 | |
dc.description | 7 | |
dc.description | 633 | |
dc.description | 638 | |
dc.description | Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil | |
dc.description | Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil [2009/10771-9] | |
dc.description | Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Brazil [301052/2009-3] | |
dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.language | English | |
dc.publisher | Elsevier Sci Ltd | |
dc.publisher | Oxford | |
dc.relation | Asian Pacific Journal of Tropical Medicine | |
dc.rights | fechado | |
dc.source | WOS | |
dc.subject | Leishmaniosis | |
dc.subject | Hypoxia Inducible Factor | |
dc.subject | Resveratrol | |
dc.subject | Echinomycin | |
dc.subject | Cdcl2 | |
dc.subject | Mimosine | |
dc.title | Evaluation Of Hypoxia Inducible Factor Targeting Pharmacological Drugs As Antileishmanial Agents | |
dc.type | Artículos de revistas | |