Prevalence Of Potential Drug-drug Interactions In The Intensive Care Unit Of A Brazilian Teaching Hospital

dc.creatorRodrigues
dc.creatorAline Teotonio; Stahlschmidt
dc.creatorRebeca; Granja
dc.creatorSilvia; Pilger
dc.creatorDiogo; Eiras Falcao
dc.creatorAntonio Luis; Mazzola
dc.creatorPriscila Gava
dc.date2017
dc.date2017-11-13T13:43:49Z
dc.date2017-11-13T13:43:49Z
dc.date.accessioned2018-03-29T05:58:32Z
dc.date.available2018-03-29T05:58:32Z
dc.identifierBrazilian Journal Of Pharmaceutical Sciences. Univ São Paulo Conjunto Quimicas, v. 53, p. , 2017.
dc.identifier1984-8250
dc.identifier2175-9790
dc.identifierWOS:000400155300025
dc.identifier10.1590/s2175-97902017000116109
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100624&lng=en&tlng=en
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/328646
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1365671
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionPatients in intensive care unit are prescribed large numbers of drugs, highlighting the need to study potential Drug-Drug Interactions in this environment. The aim of this study was to delineate the prevalence and risk of potential drug-drug interactions between medications administered to patients in an ICU. This cross-sectional observational study was conducted during 12 months, in an adult ICU of a teaching hospital. Inclusion criteria were: prescriptions with 2 or more drugs of patients admitted to the ICU for > 24 hours and age of >= 18 years. Potential Drug-Drug Interactions were quantified and classified through Micromedex (TM) database. The 369 prescriptions included in this study had 205 different drugs, with an average of 13.04 +/- 4.26 ( mean +/- standard deviation) drugs per prescription. Potential Drug-Drug Interactions were identified in 89% of these, with an average of 5.00 +/- 5.06 interactions per prescription. Of the 405 different pairs of potentially interacting drugs identified, moderate and major interactions were present in 74% and 67% of prescriptions, respectively. The most prevalent interaction was between dipyrone and enoxaparin (35.8%), though its clinical occurrence was not observed in this study. The number of potential Drug-Drug Interactions showed significant positive correlations with the length of stay in the intensive care unit, and with the number of prescribed drugs. Acknowledging the high potential for Drug-Drug Interactions in the ICU represents an important step toward improving patient safety and best therapy results.
dc.description53
dc.description1
dc.descriptionNational Council of Technological and Scientific Development (CNPq. Brasilia, DF, Brazil)
dc.descriptionSao Paulo Research Foundation (FAPESP. Sao Paulo, SP, Brazil)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageEnglish
dc.publisherUniv São Paulo Conjunto Quimicas
dc.publisherSão Paulo
dc.relationBrazilian Journal of Pharmaceutical Sciences
dc.rightsaberto
dc.sourceWOS
dc.subjectPotential Drug-drug Interactions
dc.subjectIntensive Care Unit
dc.subjectPatient Safety
dc.subjectUniversity Hospitals
dc.titlePrevalence Of Potential Drug-drug Interactions In The Intensive Care Unit Of A Brazilian Teaching Hospital
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución