dc.creatorOliveira
dc.creatorCristhian S.; Salvador
dc.creatorMarcos J.; de Carvalho
dc.creatorJoao E.; Santos
dc.creatorElide P.; Barison
dc.creatorAndersson; Stefanello
dc.creatorMaria Elida A.
dc.date2016
dc.dateset
dc.date2017-11-13T13:25:14Z
dc.date2017-11-13T13:25:14Z
dc.date.accessioned2018-03-29T05:57:39Z
dc.date.available2018-03-29T05:57:39Z
dc.identifierPhytochemistry Letters. Elsevier Science Bv, v. 17, p. 140 - 143, 2016.
dc.identifier1874-3900
dc.identifier1876-7486
dc.identifierWOS:000389521400025
dc.identifier10.1016/j.phytol.2016.07.005
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S1874390016301021
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/328461
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1365486
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionA bioassay-guided fractionation of Salvia lachnostachys Benth leaf extract led to the isolation of three known diterpenes, namely fruticuline A (1), fruticuline B (2) and 7,20-dihydrofruticuline A (3), together with two new compounds, 4 and 5. The structures were mainly elucidated by 1D and 2D NMR spectroscopy and HRESIMS. The cytotoxic activity of the crude ethanol extract, the semi-purified fractions (A-E) and compounds 1, 2 and 4 were evaluated against seven human Cancer Cell lines and the normal cell line HaCat. The ethanol extract showed activity against all tested cell lines (GI(50) 25.0-44.0 mu g/mL). Among the fractions, the greatest activity was exhibited by fraction A (eluted with hexane), which inhibited the growth of all tested cell lines with GI(50) of 3.9-19.5 mu g/mL. Compounds 1 and 4 were the most active, inhibiting the growth of U251, MCF-7, NCI-ADR/RES, 786.0, NCI-H460, PC-3, OVCAR-03 and HaCat cell lines with GI(50) < 10 mu M. Compound 2 showed moderate activity against MCF-7, NCI-H460, OVCAR-03, K562 and HaCat, with GI(50) varying 19.9-29.3 mu M. (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.
dc.description17
dc.description140
dc.description143
dc.descriptionCAPES
dc.descriptionCNPq
dc.descriptionFAPESP
dc.descriptionFundacao Araucaria [38394/2014]
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageEnglish
dc.publisherElsevier Science BV
dc.publisherAmsterdam
dc.relationPhytochemistry Letters
dc.rightsfechado
dc.sourceWOS
dc.subjectSalvia Lachnostachys
dc.subjectLamiaceae
dc.subjectDiterpenes
dc.subjectFruticuline A
dc.subjectCytotoxic Activity
dc.titleCytotoxic Abietane-derivative Diterpenoids Of Salvia Lachnostachys
dc.typeArtículos de revistas


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