| dc.creator | Oliveira | |
| dc.creator | Cristhian S.; Salvador | |
| dc.creator | Marcos J.; de Carvalho | |
| dc.creator | Joao E.; Santos | |
| dc.creator | Elide P.; Barison | |
| dc.creator | Andersson; Stefanello | |
| dc.creator | Maria Elida A. | |
| dc.date | 2016 | |
| dc.date | set | |
| dc.date | 2017-11-13T13:25:14Z | |
| dc.date | 2017-11-13T13:25:14Z | |
| dc.date.accessioned | 2018-03-29T05:57:39Z | |
| dc.date.available | 2018-03-29T05:57:39Z | |
| dc.identifier | Phytochemistry Letters. Elsevier Science Bv, v. 17, p. 140 - 143, 2016. | |
| dc.identifier | 1874-3900 | |
| dc.identifier | 1876-7486 | |
| dc.identifier | WOS:000389521400025 | |
| dc.identifier | 10.1016/j.phytol.2016.07.005 | |
| dc.identifier | http://www.sciencedirect.com/science/article/pii/S1874390016301021 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/328461 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1365486 | |
| dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
| dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
| dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.description | A bioassay-guided fractionation of Salvia lachnostachys Benth leaf extract led to the isolation of three known diterpenes, namely fruticuline A (1), fruticuline B (2) and 7,20-dihydrofruticuline A (3), together with two new compounds, 4 and 5. The structures were mainly elucidated by 1D and 2D NMR spectroscopy and HRESIMS. The cytotoxic activity of the crude ethanol extract, the semi-purified fractions (A-E) and compounds 1, 2 and 4 were evaluated against seven human Cancer Cell lines and the normal cell line HaCat. The ethanol extract showed activity against all tested cell lines (GI(50) 25.0-44.0 mu g/mL). Among the fractions, the greatest activity was exhibited by fraction A (eluted with hexane), which inhibited the growth of all tested cell lines with GI(50) of 3.9-19.5 mu g/mL. Compounds 1 and 4 were the most active, inhibiting the growth of U251, MCF-7, NCI-ADR/RES, 786.0, NCI-H460, PC-3, OVCAR-03 and HaCat cell lines with GI(50) < 10 mu M. Compound 2 showed moderate activity against MCF-7, NCI-H460, OVCAR-03, K562 and HaCat, with GI(50) varying 19.9-29.3 mu M. (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved. | |
| dc.description | 17 | |
| dc.description | 140 | |
| dc.description | 143 | |
| dc.description | CAPES | |
| dc.description | CNPq | |
| dc.description | FAPESP | |
| dc.description | Fundacao Araucaria [38394/2014] | |
| dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
| dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
| dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.language | English | |
| dc.publisher | Elsevier Science BV | |
| dc.publisher | Amsterdam | |
| dc.relation | Phytochemistry Letters | |
| dc.rights | fechado | |
| dc.source | WOS | |
| dc.subject | Salvia Lachnostachys | |
| dc.subject | Lamiaceae | |
| dc.subject | Diterpenes | |
| dc.subject | Fruticuline A | |
| dc.subject | Cytotoxic Activity | |
| dc.title | Cytotoxic Abietane-derivative Diterpenoids Of Salvia Lachnostachys | |
| dc.type | Artículos de revistas | |
