Micro-ct Evaluation Of The Radioprotective Effect Of Resveratrol On The Mandibular Incisors Of Irradiated Rats

dc.creatorDe Rezende Barbosa
dc.creatorGabriella Lopes; Pimenta
dc.creatorLuiz Andre; de Almeida
dc.creatorSolange Maria
dc.date2016
dc.date2017-11-13T13:24:50Z
dc.date2017-11-13T13:24:50Z
dc.date.accessioned2018-03-29T05:57:18Z
dc.date.available2018-03-29T05:57:18Z
dc.identifierBrazilian Oral Research. Sociedade Brasileira De Pesquisa Odontologica, v. 30, p. , 2016.
dc.identifier1806-8324
dc.identifier1678-8079
dc.identifierWOS:000378324000050
dc.identifier10.1590/1807-3107BOR-2016.vol30.0168
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242016000100229&lng=en&tlng=en
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/328381
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1365406
dc.descriptionThe purpose of this study was to perform a microcomputed tomographic evaluation of the radioprotective effect of resveratrol on the volume of mandibular incisors of irradiated rats. A second aim was to make a quantitative assessment of the effect of x-ray exposure on these dental tissues. Twenty adult male rats were divided into four groups: control, irradiated control, resveratrol, and irradiated resveratrol. The resveratrol groups received 100 mg/kg of resveratrol, whereas the irradiated groups were exposed to 15 Gy of irradiation. The animals were sacrificed 30 days after the irradiation procedure, and their mandibles were removed and scanned in a microcomputed tomography unit. The images were loaded into Mimics software to allow segmentation of the mandibular incisor and assessment of its volume. The results were compared by One-way ANOVA and Tukey's post hoc test, considering a 5% significance level. The irradiated groups showed significantly diminished volumes of the evaluated teeth, as compared with the control group (p < 0.05). The resveratrol group presented higher values than those of the irradiated groups, and volumes similar to those of the control group. High radiation doses significantly affected tooth formation, resulting in alterations in the dental structure, and thus lower volumes. Moreover, resveratrol showed no effective radioprotective impact on dental tissues. Future studies are needed to evaluate different concentrations of this substance, in an endeavor to verify its potential as a radioprotector for these dental tissues.
dc.description30
dc.description1
dc.languageEnglish
dc.publisherSociedade Brasileira de Pesquisa Odontologica
dc.publisherSão Paulo
dc.relationBrazilian Oral Research
dc.rightsaberto
dc.sourceWOS
dc.subjectOdontogenesis
dc.subjectRadiation-protective Agents
dc.subjectRadiation Injuries
dc.subjectX-ray Microtomography
dc.titleMicro-ct Evaluation Of The Radioprotective Effect Of Resveratrol On The Mandibular Incisors Of Irradiated Rats
dc.typeArtículos de revistas


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