dc.creatorBiller
dc.creatorPriscila; Gueguen
dc.creatorLaurent; Knibbe
dc.creatorCarole; Tannier
dc.creatorEric
dc.date2016
dc.datemaio
dc.date2017-11-13T13:24:38Z
dc.date2017-11-13T13:24:38Z
dc.date.accessioned2018-03-29T05:57:11Z
dc.date.available2018-03-29T05:57:11Z
dc.identifierGenome Biology And Evolution. Oxford Univ Press, v. 8, p. 1427 - 1439, 2016.
dc.identifier1759-6653
dc.identifierWOS:000378633000012
dc.identifier10.1093/gbe/evw083
dc.identifierhttps://academic.oup.com/gbe/article-lookup/doi/10.1093/gbe/evw083
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/328350
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1365375
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionModels of evolution by genome rearrangements are prone to two types of flaws: One is to ignore the diversity of susceptibility to breakage across genomic regions, and the other is to suppose that susceptibility values are given. Without necessarily supposing their precise localization, we call "solid" the regions that are improbably broken by rearrangements and "fragile" the regions outside solid ones. We propose a model of evolution by inversions where breakage probabilities vary across fragile regions and over time. It contains as a particular case the uniform breakage model on the nucleotidic sequence, where breakage probabilities are proportional to fragile region lengths. This is very different from the frequently used pseudouniform model where all fragile regions have the same probability to break. Estimations of rearrangement distances based on the pseudouniform model completely fail on simulations with the truly uniform model. On pairs of amniote genomes, we show that identifying coding genes with solid regions yields incoherent distance estimations, especially with the pseudouniform model, and to a lesser extent with the truly uniform model. This incoherence is solved when we coestimate the number of fragile regions with the rearrangement distance. The estimated number of fragile regions is surprisingly Small, suggesting that a minority of regions are recurrently used by rearrangements. Estimations for several pairs of genomes at different divergence times are in agreement with a slowly evolvable colocalization of active genomic regions in the cell.
dc.description8
dc.description5
dc.description1427
dc.description1439
dc.descriptionFAPESP [2013/25084-2]
dc.descriptionFrench Agence Nationale de la Recherche (ANR) [ANR-10-BINF-01-01]
dc.descriptionICT FP7 european programme EVOEVO
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageEnglish
dc.publisherOxford Univ Press
dc.publisherOxford
dc.relationGenome Biology And Evolution
dc.rightsaberto
dc.sourceWOS
dc.subjectRearrangements
dc.subjectInversions
dc.subjectRandom Graphs
dc.subjectAmniote Genomes
dc.subjectUniform Breakpoint Model
dc.subjectFragile Breakpoint Model
dc.titleBreaking Good: Accounting For Fragility Of Genomic Regions In Rearrangement Distance Estimation
dc.typeArtículos de revistas


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