Tolerogenic Vaccination With Mog/vitd Overcomes Aggravating Effect Of C-albicans In Experimental Encephalomyelitis

dc.creatorFraga-Silva
dc.creatorThais F. C.; Mimura
dc.creatorLuiza A. N.; Zorzella-Pezavento
dc.creatorSofia F. G.; Ishikawa
dc.creatorLarissa L. W.; Franca
dc.creatorThais G. D.; Thome
dc.creatorRodolfo; Verinaud
dc.creatorLiana; Arruda
dc.creatorMaria S. P.; Sartori
dc.creatorAlexandrina
dc.date2016
dc.dateout
dc.date2017-11-13T13:24:35Z
dc.date2017-11-13T13:24:35Z
dc.date.accessioned2018-03-29T05:57:08Z
dc.date.available2018-03-29T05:57:08Z
dc.identifierCns Neuroscience & Therapeutics. Wiley-blackwell, v. 22, p. 807 - 816, 2016.
dc.identifier1755-5930
dc.identifier1755-5949
dc.identifierWOS:000383628000001
dc.identifier10.1111/cns.12572
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1111/cns.12572/abstract
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/328336
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1365361
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionMultiple sclerosis (MS) is an immune-mediated demyelinating disorder of the central nervous system (CNS). We described that Candida albicans (Ca) aggravates experimental autoimmune encephalomyelitis (EAE) that is a model to study MS. We also observed that vaccination with a myelin peptide (MOG) in the presence of vitamin D (VitD) protected mice against EAE. In this work, we investigated whether Ca infection interferes with the efficacy of this vaccine. MethodsEAE was induced in C57BL/6 female mice previously vaccinated with MOG+VitD and then infected 3 days before encephalomyelitis induction. ResultsVaccination was able to control EAE development in infected mice. These animals gained weight, and only a few progressed to very low clinical scores. Protection was confirmed by a lower inflammatory infiltration in the CNS and was also associated with a reduced production of encephalitogenic cytokines by spleen and CNS cell cultures. The elevated percentage of CD25(+)FoxP3(+) cells suggests that regulatory T cells are involved in the protection. Adoptive transfer of splenocytes from mice vaccinated with MOG+VitD supports the view that protection is mediated by immunoregulatory cells. ConclusionTogether, these experiments provide evidence demonstrating that EAE can be prevented by the inverse vaccination with MOG+VitD even in the presence of a disease-aggravating infectious agent.
dc.description22
dc.description10
dc.description807
dc.description816
dc.descriptionSao Paulo Research Foundation (FAPESP) [2012/12540-7]
dc.descriptionFAPESP [2013/ 14353-2]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageEnglish
dc.publisherWiley-Blackwell
dc.publisherHoboken
dc.relationCNS Neuroscience & Therapeutics
dc.rightsfechado
dc.sourceWOS
dc.subjectActive Vitamin D
dc.subjectDisseminated Candidiasis
dc.subjectMultiple Sclerosis
dc.subjectMyelin Oligodendrocyte Glycoprotein
dc.subjectTolerogenic Vaccination
dc.titleTolerogenic Vaccination With Mog/vitd Overcomes Aggravating Effect Of C-albicans In Experimental Encephalomyelitis
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución