Hierarchical Structures Of Beta-tcp/45s5 Bioglass Hybrid Scaffolds Prepared By Gelcasting

dc.creatorLopes
dc.creatorJoao Henrique; Magalhae
dc.creatorJessica Aparecida; Gouueia
dc.creatorRubia Figueredo; Bertran
dc.creatorCelso Aparecido; Motisuke
dc.creatorMariana; Camargo
dc.creatorSamira E. A.; Triches
dc.creatorEliandra de Sousa
dc.date2016
dc.dateset
dc.date2017-11-13T13:24:28Z
dc.date2017-11-13T13:24:28Z
dc.date.accessioned2018-03-29T05:57:00Z
dc.date.available2018-03-29T05:57:00Z
dc.identifierJournal Of The Mechanical Behavior Of Biomedical Materials. Elsevier Science Bv, v. 62, p. 10 - 23, 2016.
dc.identifier1751-6161
dc.identifier1878-0180
dc.identifierWOS:000381238500002
dc.identifier10.1016/j.jmbbm.2016.04.028
dc.identifierhttps://www.pubfacts.com/detail/27161958/Hierarchical-structures-of-TCP45S5-bioglass-hybrid-scaffolds-prepared-by-gelcasting
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/328307
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1365332
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThis paper investigates the microstructure and the mechanical properties of beta-tricalcium phosphate (beta-TCP) three-dimensional (3D) porous materials reinforced with 45S5 bioactive glass (BG). beta-TCP and beta-TCP/x%-BG scaffolds with interconnected pores networks, suitable for bone regeneration, were fabricated by gel-casting method. Mechanical properties, porosity, and morphological characteristics were evaluated by compressive strength test, scanning electron microscopy (SEM) and X-ray micro tomography analysis, whereas the structures were fully explored by XRD, and Raman spectroscopy. To the best of our knowledge, this is the first time where the mechanism for understanding the effect of bioglass on the mechanical properties and microstruture of beta-TCP/45S5-BG scaffolds has been systematically studied. The findings showed that ionic product lixiviated from 45S5 bioactive glass, rich in silicon species and sodium ion, catalyzes a phase transition from beta-TCP to Si-TCP by replacement of phosphorus for silicon and contributes to the improvement of scaffolds mechanical properties. The compressive strength of beta-TCP/5%-BG and beta-TCP/7.5%-BG was improved around 200% in comparison to pure beta-TCP. Osteoblast-like cells (MG 63) were exposed to the materials for 24 h through the use of medium conditioned by beta-tricalcium phosphate/bioactive glass. Cell viability was measured by MTT assay in the cells and the data obtained were submitted to ANovA, Tukey's multiple comparison (p<0.05). The beta-TCP/7.5-BG promoted an increase of cell proliferation. The results suggest that compositions and processing method studied may provide appropriate materials for tissue engineering. (C) 2016 Elsevier Ltd. All rights reserved.
dc.description62
dc.description10
dc.description23
dc.descriptionSao Paulo Research Foundation - FAPESP [2010/12376-5, 2010/00863-0, 2011/09240-9, 2011/17877-7]
dc.descriptionNational Council for Scientific and Technological Development (CNPq/PIBITI) [456461/2014-0]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageEnglish
dc.publisherElsevier Science BV
dc.publisherAmsterdam
dc.relationJournal of The Mechanical Behavior of Biomedical Materials
dc.rightsfechado
dc.sourceWOS
dc.subjectBeta-tcp
dc.subject45s5 Bioglass
dc.subjectScaffolds
dc.subjectGelcasting
dc.subjectBioactivity
dc.titleHierarchical Structures Of Beta-tcp/45s5 Bioglass Hybrid Scaffolds Prepared By Gelcasting
dc.typeArtículos de revistas


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