Detection Of Pup Odors By Non-canonical Adult Vomeronasal Neurons Expressing An Odorant Receptor Gene Is Influenced By Sex And Parenting Status

dc.creatorNakahara
dc.creatorThiago S.; Cardozo
dc.creatorLeonardo M.; Ibarra-Soria
dc.creatorXimena; Bard
dc.creatorAndrew D.; Carvalho
dc.creatorVinicius M. A.; Trintinalia
dc.creatorGuilherme Z.; Logan
dc.creatorDarren W.; Papes
dc.creatorFabio
dc.date2016
dc.datefev
dc.date2017-11-13T13:24:07Z
dc.date2017-11-13T13:24:07Z
dc.date.accessioned2018-03-29T05:56:39Z
dc.date.available2018-03-29T05:56:39Z
dc.identifierBmc Biology. Biomed Central Ltd, v. 14, p. , 2016.
dc.identifier1741-7007
dc.identifierWOS:000370007400001
dc.identifier10.1186/s12915-016-0234-9
dc.identifierhttps://www-biomedcentral-com.ez88.periodicos.capes.gov.br/1741-7007/14/12
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/328235
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1365260
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionOlfaction is a fundamental sense through which most animals perceive the external world. The olfactory system detects odors via specialized sensory organs such as the main olfactory epithelium and the vomeronasal organ. Sensory neurons in these organs use G-protein coupled receptors to detect chemosensory stimuli. The odorant receptor (OR) family is expressed in sensory neurons of the main olfactory epithelium, while the adult vomeronasal organ is thought to express other types of receptors. Results: Here, we describe Olfr692, a member of the OR gene family identified by next-generation RNA sequencing, which is highly upregulated and non-canonically expressed in the vomeronasal organ. We show that neurons expressing this gene are activated by odors emanating from pups. Surprisingly, activity in Olfr692-positive cells is sexually dimorphic, being very low in females. Our results also show that juvenile odors activate a large number of Olfr692 vomeronasal neurons in virgin males, which is correlated with the display of infanticide behavior.. In contrast, activity substantially decreases in parenting males (fathers), where infanticidal aggressive behavior is not frequently observed. Conclusions: Our results describe, for the first time, a sensory neural population with a specific molecular identity involved in the detection of pup odors. Moreover, it is one of the first reports of a group of sensory neurons the activity of which is sexually dimorphic and depends on social status. Our data suggest that the Olfr692 population is involved in mediating pup-oriented behaviors in mice.
dc.description14
dc.descriptionSao Paulo Research Foundation (FAPESP) Young Principal Investigator award [09/00473-0]
dc.descriptionFAPESP fellowships
dc.descriptionCAPES fellowship
dc.descriptionWellcome Trust [098051]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageEnglish
dc.publisherBiomed Central Ltd
dc.publisherLondon
dc.relationBMC Biology
dc.rightsaberto
dc.sourceWOS
dc.subjectOlfaction
dc.subjectOdorant Receptor
dc.subjectPup Odors
dc.subjectSexual Dimorphism
dc.subjectSocial Behavior
dc.subjectVomeronasal Organ
dc.titleDetection Of Pup Odors By Non-canonical Adult Vomeronasal Neurons Expressing An Odorant Receptor Gene Is Influenced By Sex And Parenting Status
dc.typeArtículos de revistas


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