Elevated Serum Uric Acid Is Associated With Vascular Inflammation But Not Coronary Artery Calcification In The Healthy Octogenarians: The Brazilian Study On Healthy Aging

dc.creatorMalik
dc.creatorRehan; Aneni
dc.creatorEhimen C.; Shahrayar
dc.creatorSameer; Freitas
dc.creatorWladimir M.; Ali
dc.creatorShozab S.; Veledar
dc.creatorEmir; Latif
dc.creatorMuhammad A.; Aziz
dc.creatorMuhammad; Ahmed
dc.creatorRameez; Khan
dc.creatorSher A.; Joseph
dc.creatorJeffrin; Feiz
dc.creatorHamid; Sposito
dc.creatorAndrei; Nasir
dc.creatorKhurram
dc.date2016
dc.dateabr
dc.date2017-11-13T13:23:06Z
dc.date2017-11-13T13:23:06Z
dc.date.accessioned2018-03-29T05:55:49Z
dc.date.available2018-03-29T05:55:49Z
dc.identifierAging Clinical And Experimental Research. Springer, v. 28, p. 359 - 362, 2016.
dc.identifier1594-0667
dc.identifier1720-8319
dc.identifierWOS:000372884600024
dc.identifier10.1007/s40520-015-0395-3
dc.identifierhttps://link.springer.com/article/10.1007/s40520-015-0395-3
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/328034
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1365059
dc.descriptionThere is a limited data on the association between serum uric acid (SUA) and cardiovascular disease (CVD) among the very elderly population. We evaluated the association of SUA, highly sensitive C-reactive protein (hs-CRP, a marker of vascular and systemic inflammation), and coronary artery calcification (CAC, a marker of subclinical CVD) in a cohort of Brazilian octogenarians (a parts per thousand yen80 years) free from known clinical CVD. 208 individuals were included and evaluated for an association between increasing tertiles of SUA, elevated hs-CRP (> 3 mg/dL), the presence and burden of CAC (CAC > 0 and CAC > 400). The median hs-CRP was 1.9 (IQR = 1.0-3.4) mg/L and mean SUA was 5.3 (+/- 1.4) mg/dL. The overall prevalence of elevated hs-CRP (> 3 mg/dL) was 31 %. A significant increase in the prevalence of hs-CRP was noted across the higher SUA tertiles (p < 0.001) with 3.4 times the odds of having elevated hs-CRP in the highest SUA tertile (3.40; CI = 1.27-9.08). No association was noted with either the CAC presence and/or CAC burden (CAC > 0 or CAC > 400) across the increasing SUA tertiles. In the healthy octogenarians, higher SUA levels are associated with vascular inflammation (hs-CRP) but not with coronary atherosclerosis (CAC); markers for the subclinical CVD.
dc.description28
dc.description2
dc.description359
dc.description362
dc.languageEnglish
dc.publisherSpringer
dc.publisherNew York
dc.relationAging Clinical and Experimental Research
dc.rightsfechado
dc.sourceWOS
dc.subjectOctogenarians
dc.subjectSubclinical Cvd
dc.subjectCac
dc.subjectHs-crp And Serum Uric Acid
dc.titleElevated Serum Uric Acid Is Associated With Vascular Inflammation But Not Coronary Artery Calcification In The Healthy Octogenarians: The Brazilian Study On Healthy Aging
dc.typeArtículos de revistas


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