The Total Synthesis Of Calcium Atorvastatin

dc.creatorDias
dc.creatorLuiz C.; Vieira
dc.creatorAdriano S.; Barreiro
dc.creatorEliezer J.
dc.date2016
dc.date2017-11-13T13:21:26Z
dc.date2017-11-13T13:21:26Z
dc.date.accessioned2018-03-29T05:54:39Z
dc.date.available2018-03-29T05:54:39Z
dc.identifierOrganic & Biomolecular Chemistry. Royal Soc Chemistry, v. 14, p. 2291 - 2296, 2016.
dc.identifier1477-0520
dc.identifier1477-0539
dc.identifierWOS:000370878800019
dc.identifier10.1039/c5ob02546j
dc.identifierhttp://pubs.rsc.org/en/Content/ArticleLanding/2016/OB/C5OB02546J#!divAbstract
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/327753
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1364778
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionA practical and convergent asymmetric route to calcium atorvastatin (1) is reported. The synthesis of calcium atorvastatin (1) was performed using the remote 1,5-anti asymmetric induction in the boron-mediated aldol reaction of beta-alkoxy methylketone (4) with pyrrolic aldehyde (3) as a key step. Calcium atorvastatin was obtained from aldehyde (3) after 6 steps, with a 41% overall yield.
dc.description14
dc.description7
dc.description2291
dc.description2296
dc.descriptionCNPq (INCT-INOFAR) [CNPq 573.564/2008-6, FAPERJ E-26/170.020/2008]
dc.descriptionCristalia Produtos Quimicos Farmaceuticos
dc.descriptionFAPESP [2012/02230-0]
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageEnglish
dc.publisherRoyal Soc Chemistry
dc.publisherCambrigde
dc.relationOrganic & Biomolecular Chemistry
dc.rightsfechado
dc.sourceWOS
dc.titleThe Total Synthesis Of Calcium Atorvastatin
dc.typeArtículos de revistas


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