Exposure To High Endotoxin Concentration Increases Wheezing Prevalence Among Laboratory Animal Workers: A Cross-sectional Study

dc.creatorFreitas
dc.creatorAmanda Souza; Simoneti
dc.creatorChristian Silva; Ferraz
dc.creatorErica; Bagatin
dc.creatorEricson; Brandao
dc.creatorIzaira Tincani; Silva
dc.creatorCelio Lopes; Borges
dc.creatorMarcos Carvalho; Vianna
dc.creatorElcio Oliveira
dc.date2016
dc.datemaio
dc.date2017-11-13T13:21:06Z
dc.date2017-11-13T13:21:06Z
dc.date.accessioned2018-03-29T05:54:27Z
dc.date.available2018-03-29T05:54:27Z
dc.identifierBmc Pulmonary Medicine. Biomed Central Ltd, v. 16, p. , 2016.
dc.identifier1471-2466
dc.identifierWOS:000375959100001
dc.identifier10.1186/s12890-016-0233-1
dc.identifierhttps://bmcpulmmed.biomedcentral.com.ez88.periodicos.capes.gov.br/articles/10.1186/s12890-016-0233-1
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/327717
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1364742
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionEndotoxin from Gram-negative bacteria are found in different concentrations in dust and on the ground of laboratories dealing with small animals and animal houses. Methods: Cross-sectional study performed in workplaces of two universities. Dust samples were collected from laboratories and animal facilities housing rats, mice, guinea pigs, rabbits or hamsters and analyzed by the "Limulus amebocyte lysate" (LAL) method. We also sampled workplaces without animals. The concentrations of endotoxin detected in the workplaces were tested for association with wheezing in the last 12 months, asthma defined by self-reported diagnosis and asthma confirmed by bronchial hyperresponsiveness (BHR) to mannitol. Results: Dust samples were obtained at 145 workplaces, 92 with exposure to animals and 53 with no exposure. Exposed group comprised 412 subjects and non-exposed group comprised 339 subjects. Animal-exposed workplaces had higher concentrations of endotoxin, median of 34.2 endotoxin units (EU) per mg of dust (interquartile range, 12.6-65.4), as compared to the non-exposed group, median of 10.2 EU/mg of dust (interquartile range, 2.6-22.2) (p < 0.001). The high concentration of endotoxin (above whole sample median, 20.4 EU/mg) was associated with increased wheezing prevalence (p < 0.001), i.e., 61 % of workers exposed to high endotoxin concentration reported wheezing in the last 12 months compared to 29 % of workers exposed to low endotoxin concentration. The concentration of endotoxin was not associated with asthma report or with BHR confirmed asthma. Conclusion: Exposure to endotoxin is associated with a higher prevalence of wheezing, but not with asthma as defined by the mannitol bronchial challenge test or by self- reported asthma. Preventive measures are necessary for these workers.
dc.description16
dc.description69
dc.descriptionSao Paulo Research Foundation (FAPESP)
dc.descriptionNational Council of Technological and Scientific Development (CNPq), Brazil
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageEnglish
dc.publisherBIOMED CENTRAL LTD
dc.publisherLondon
dc.relationBMC Pulmonary Medicine
dc.rightsaberto
dc.sourceWOS
dc.subjectEndotoxin
dc.subjectWheezing
dc.subjectOccupational Disease
dc.subjectAnimal Handler
dc.titleExposure To High Endotoxin Concentration Increases Wheezing Prevalence Among Laboratory Animal Workers: A Cross-sectional Study
dc.typeArtículos de revistas


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