Selection On Different Genes With Equivalent Functions: The Convergence Story Told By Hox Genes Along The Evolution Of Aquatic Mammalian Lineages

dc.creatorNery
dc.creatorMariana F.; Borges
dc.creatorBrunno; Dragalzew
dc.creatorAline C.; Kohlsdorf
dc.creatorTiana
dc.date2016
dc.datemaio
dc.date2017-11-13T13:20:50Z
dc.date2017-11-13T13:20:50Z
dc.date.accessioned2018-03-29T05:54:19Z
dc.date.available2018-03-29T05:54:19Z
dc.identifierBmc Evolutionary Biology. Biomed Central Ltd, v. 16, p. , 2016.
dc.identifier1471-2148
dc.identifierWOS:000376370100002
dc.identifier10.1186/s12862-016-0682-4
dc.identifierhttps://bmcevolbiol.biomedcentral.com.ez88.periodicos.capes.gov.br/articles/10.1186/s12862-016-0682-4
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/327688
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1364713
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionConvergent evolution has been a challenging topic for decades, being cetaceans, pinnipeds and sirenians textbook examples of three independent origins of equivalent phenotypes. These mammalian lineages acquired similar anatomical features correlated to an aquatic life, and remarkably differ from their terrestrial counterparts. Whether their molecular evolutionary history also involved similar genetic mechanisms underlying such morphological convergence nevertheless remained unknown. To test for the existence of convergent molecular signatures, we studied the molecular evolution of Hox genes in these three aquatic mammalian lineages, comparing their patterns to terrestrial mammals. Hox genes are transcription factors that play a pivotal role in specifying embryonic regional identity of nearly any bilateral animal, and are recognized major agents for diversification of body plans. Results: We detected few signatures of positive selection on Hox genes across the three aquatic mammalian lineages and verified that purifying selection prevails in these sequences, as expected for pleiotropic genes. Genes found as being positively selected differ across the aquatic mammalian lineages, but we identified a substantial overlap of their developmental functions. Such pattern likely resides on the duplication history of Hox genes, which probably provided different possible evolutionary routes for achieving the same phenotypic solution. Conclusions: Our results indicate that convergence occurred at a functional level of Hox genes along three independent origins of aquatic mammals. This conclusion reinforces the idea that different changes in developmental genes may lead to similar phenotypes, probably due to the redundancy provided by the participation of Hox paralogous genes in several developmental functions.
dc.description16
dc.descriptionCiencia sem Fronteiras - Atracao de Jovens Talentos CAPES [054/2012]
dc.descriptionFAPESP-Brazil [2010/52316-3]
dc.descriptionCNPq-Brazil [563232/2010-2]
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageEnglish
dc.publisherBiomed Central Ltd
dc.publisherLondon
dc.relationBMC Evolutionary Biology
dc.rightsaberto
dc.sourceWOS
dc.subjectCetaceans
dc.subjectPinnipeds
dc.subjectSirenians
dc.subjectMolecular Evolution
dc.subjectHox Genes
dc.subjectPositive Selection
dc.titleSelection On Different Genes With Equivalent Functions: The Convergence Story Told By Hox Genes Along The Evolution Of Aquatic Mammalian Lineages
dc.typeArtículos de revistas


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