Artículos de revistas
Influence Of Cigarette Smoking On Cardiac Biomarkers: The Arherosclerosis Risk In Communities (aric) Study
Registro en:
European Journal Of Heart Failure. Wiley-blackwell, v. 18, p. 629 - 637, 2016.
1388-9842
1879-0844
WOS:000379257200007
10.1002/ejhf.511
Autor
Nadruz
Wilson
Jr.; Goncalves
Alexandra; Claggett
Brian; Roca
Gabriela Querejeta; Shah
Amil M.; Cheng
Susan; Heiss
Gerardo; Ballantyne
Christie M.; Solomon
Scott D.
Institución
Resumen
Cigarette smoking has been associated with incident heart failure independent of coronary artery disease (CAD), but the mechanisms linking smoking to cardiac damage are not well understood. This study sought to evaluate the relationship between smoking and N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity Troponin T (hs-TnT), which are, respectively, biomarkers of myocardial wall stress and injury, in a large community-based cohort. Methods and resultsWe examined the association between smoking history and NT-proBNP and hs-TnT in 9649 participants free of overt CAD or heart failure from the Atherosclerosis Risk in Communities (ARIC) Study who attended Visit 4 (1996-1998), as well as the association with change in these biomarkers from Visit 4 to Visit 5 (2011-2013) in 3151 participants. At Visit 4, higher cumulative cigarette exposure, assessed by total pack-years, was associated with elevated levels of NT-proBNP (P<0.001) and hs-TnT (P=0.01) among ever smokers in multivariable analyses adjusted for potential confounders. After 15years of follow-up, participants who were active smokers at Visit 4 had greater incidence of elevated NT-proBNP {adjusted proportion=48% [95% confidence interval (CI) 41, 54] vs. 35 (95% CI 32, 39); P=0.006} and hs-TnT [adjusted proportion=32% (95% CI 26, 38) vs. 23 (95% CI 20, 26); P=0.021] compared with never smokers, adjusting for baseline and follow-up covariates. ConclusionsIn a large community-based cohort free of overt CAD and heart failure, cigarette smoking was associated with biomarkers of myocardial wall stress and injury at baseline as well as with a continued measurable increase in these biomarkers after 15years of follow-up. 18 6 629 637 NHLBI NIH HHS [HHSN268201100005I, HHSN268201100005C, HHSN268201100005G, HHSN268201100006C, HHSN268201100007C, HHSN268201100007I, HHSN268201100008C, HHSN268201100008I, HHSN268201100009C, HHSN268201100009I, HHSN268201100010C, HHSN268201100011C, HHSN268201100011I, HHSN268201100012C, K08 HL116792, N01 HC055018, R00 HL107642]