Study Of Risk Factors For Atopic Sensitization, Asthma, And Bronchial Hyperresponsiveness In Animal Laboratory Workers

dc.creatorSimoneti
dc.creatorChristian Silva; Freitas
dc.creatorAmanda Souza; Rodrigues Barbosa
dc.creatorMichelle Christiane; Ferraz
dc.creatorErica; de Menezes
dc.creatorMarcelo Bezerra; Bagatin
dc.creatorEricson; Arruda
dc.creatorLuisa Karla; Vianna
dc.creatorElcio Oliveira
dc.date2016
dc.datejan
dc.date2017-11-13T13:15:49Z
dc.date2017-11-13T13:15:49Z
dc.date.accessioned2018-03-29T05:53:13Z
dc.date.available2018-03-29T05:53:13Z
dc.identifierJournal Of Occupational Health. Japan Soc Occupational Health, v. 58, p. 7 - 15, 2016.
dc.identifier1341-9145
dc.identifier1348-9585
dc.identifierWOS:000385911100002
dc.identifierhttps://www.jstage.jst.go.jp/article/joh/58/1/58_15-0045-OA/_article
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/327422
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1364447
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThe aim of this estudy was to investigate the influence of allergen exposure levels and other risk factors for allergic sensitization, asthma, and bronchial hyperresponsiveness (BHR) in workers exposed to laboratory animals. Methods: This was a crosssectional study performed at two universities, 123 workplaces with 737 subjects. Dust samples were collected from laboratories and animal facilities housing rats, mice, guinea pigs, rabbits, or hamsters and analyzed by enzyme-linked immunosorbent assay (ELISA) to measure allergen concentrations. We also sampled workplaces without animals. Asthma was defined by both symptoms and BHR to mannitol. The concentrations of allergens were tested for association with a skin prick test, respiratory symptoms, spirometry data, and BHR. This multivariate analysis was performed by using Poisson regression to estimate the relative risk (RR) for the exposed group. Results: Our sample comprised students and workers, with 336 subjects in the nonexposed group and 401 subjects in the exposed group. Sixty-nine subjects (17%) had positive results in the skin prick test for animal allergens in the exposed group; in the nonexposed group, 10 subjects had positive results (3%) (p<0.001). Exposure to laboratory animals over 2.8 years was associated with atopic sensitization (RR=1.85; 95% confidence interval: 1.09-3.15; p=0.02). Allergen concentration was not associated with sensitization, asthma, or BHR. Conclusion: Exposure to laboratory animals was associated with atopic sensitization. However, we did not find a cutoff allergen concentration that increased the risk for sensitization. Duration of exposure seems to be more relevant to sensitization than concentration of allergens in dust.
dc.description58
dc.description1
dc.description7
dc.description15
dc.descriptionFAPESP, Brazil
dc.descriptionCNPq, Brazil
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageEnglish
dc.publisherJapan Soc Occupational Health
dc.publisherTokyo
dc.relationJournal of Occupational Health
dc.rightsfechado
dc.sourceWOS
dc.subjectAnimal Experimentation
dc.subjectAtopy
dc.subjectBronchial Hyperreactivity
dc.subjectOccupational Disease
dc.titleStudy Of Risk Factors For Atopic Sensitization, Asthma, And Bronchial Hyperresponsiveness In Animal Laboratory Workers
dc.typeArtículos de revistas


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