Amine Bridges Grafted Mesoporous Silica, As A Prolonged/controlled Drug Release System For The Enhanced Therapeutic Effect Of Short Life Drugs

dc.creatorRehman
dc.creatorFozia; Ahmed
dc.creatorKhalid; Airoldi
dc.creatorClaudio; Gaisford
dc.creatorSimon; Buanz
dc.creatorAsma; Rahim
dc.creatorAbdur; Muhammad
dc.creatorNawshad; Volpe
dc.creatorPedro L. O.
dc.date2017
dc.datemar
dc.date2017-11-13T13:15:37Z
dc.date2017-11-13T13:15:37Z
dc.date.accessioned2018-03-29T05:53:04Z
dc.date.available2018-03-29T05:53:04Z
dc.identifierMaterials Science And Engineering: C-materials For Biological Applications. Elsevier Science Bv, v. 72, p. 34 - 41, 2017.
dc.identifier0928-4931
dc.identifier1873-0191
dc.identifierWOS:000392165600005
dc.identifier10.1016/j.msec.2016.11.040
dc.identifierhttp://www-sciencedirect-com.ez88.periodicos.capes.gov.br/science/article/pii/S0928493116308074?via%3Dihub
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/327386
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1364411
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionHybrid mesoporous silica SBA-15, with surface incorporated cross-linked long hydrophobic organic bridges was synthesized using stepwise synthesis. The synthesized materials were characterized by elemental analysis, infrared spectroscopy, nuclear magnetic resonance spectroscopy, nitrogen adsorption, X-rays diffraction, thermogravimetry and scanning and transmission electron microscopy. The functionalized material showed highly ordered mesoporous network with a surface area of 629.0 m(2) g(-1). The incorporation of long hydrophobic amine chains on silica surface resulted in high drug loading capacity (21% Mass/Mass) and prolonged release of ibuprofen up till 75.5 h. The preliminary investigations suggests that the synthesized materials could be proposed as controlled release devices to prolong the therapeutic effect of short life drugs such as ibuprofen to increase its efficacy and to reduce frequent dosage. (C) 2016 Elsevier B.V. All rights reserved.
dc.description72
dc.description34
dc.description41
dc.descriptionTWAS/CNPq [190064/2010-2]
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageEnglish
dc.publisherElsevier Science BV
dc.publisherAmsterdam
dc.relationMaterials Science and Engineering: C-Materials for Biological Applications
dc.rightsfechado
dc.sourceWOS
dc.subjectMesoporous Silica
dc.subjectSurface Modification
dc.subjectIbuprofen And Controlled Drug Release
dc.titleAmine Bridges Grafted Mesoporous Silica, As A Prolonged/controlled Drug Release System For The Enhanced Therapeutic Effect Of Short Life Drugs
dc.typeArtículos de revistas


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