How Does The Chain Length Of Peg Functionalized At The Outer Surface Of Mesoporous Silica Nanoparticles Alter The Uptake Of Molecules?

dc.creatorFonseca
dc.creatorLeandro C.; de Paula
dc.creatorAmauri J.; Martinez
dc.creatorDiego Stefani T.; Alves
dc.creatorOswaldo L.
dc.date2016
dc.date2017-11-13T13:15:22Z
dc.date2017-11-13T13:15:22Z
dc.date.accessioned2018-03-29T05:52:55Z
dc.date.available2018-03-29T05:52:55Z
dc.identifierNew Journal Of Chemistry. Royal Soc Chemistry, v. 40, p. 8060 - 8067, 2016.
dc.identifier1144-0546
dc.identifier1369-9261
dc.identifierWOS:000382820000094
dc.identifier10.1039/c6nj01316c
dc.identifierhttp://pubs.rsc.org/en/content/articlelanding/2016/nj/c6nj01316c#!divAbstract
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/327346
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1364371
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionThe current work describes the development of new mesoporous silica nanoparticles (MSNs) containing a high content of phenyl groups (hydrophobic species) inside the mesopores and externally functionalized with polyethylene glycol (PEG), a hydrophilic moiety, to provide biocompatibility and colloidal stability. The MSNs were encapsulated with curcumin, a versatile hydrophobic drug for biological use. The ability of silica nanoparticles to optimize the solubility of this biologically-active molecule in water was investigated. Nanoparticles were characterized using C-13 and Si-29 Nuclear Magnetic Resonance (NMR), thermal analysis (TGA and DTA), nitrogen sorption analysis, transmission electron microscopy (TEM), dynamic light scattering (DLS) and zeta potential (PZ). We assessed the curcumin water solubility using the pegylated nanoparticles as well as the influence of the PEG chain length (500 and 2000 Da) and its concentration on the encapsulation process. The results indicate that the higher the PEG chain length the lower the MSN encapsulation capacity for curcumin, possibly due to steric factors. However, all of the nanoparticles largely improved curcumin solubility in water.
dc.description40
dc.description9
dc.description8060
dc.description8067
dc.descriptionCAPES
dc.descriptionINCT-Inomat
dc.descriptionBrazilian Nanotoxicology Network (Cigenanotox)
dc.descriptionNanoBioss-SisNANO/MCTI
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageEnglish
dc.publisherRoyal Soc Chemistry
dc.publisherCambridge
dc.relationNew Journal of Chemistry
dc.rightsfechado
dc.sourceWOS
dc.subjectWater-soluble Drugs
dc.subjectOrganic Functionalization
dc.subjectControlled-release
dc.subjectDelivery
dc.subjectNanocarriers
dc.subjectCancer
dc.titleHow Does The Chain Length Of Peg Functionalized At The Outer Surface Of Mesoporous Silica Nanoparticles Alter The Uptake Of Molecules?
dc.typeArtículos de revistas


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