Efficacy Of Vaginally Applied Estrogen, Testosterone, Or Polyacrylic Acid On Vaginal Atrophy: A Randomized Controlled Trial

dc.creatorFernandes
dc.creatorTatiane; Costa-Paiva
dc.creatorLucia Helena; Pedro
dc.creatorAdriana Orcesi; Cintra Baccaro
dc.creatorLuiz Francisco; Pinto-Neto
dc.creatorAarao Mendes
dc.date2016
dc.datejul
dc.date2017-11-13T13:14:36Z
dc.date2017-11-13T13:14:36Z
dc.date.accessioned2018-03-29T05:52:20Z
dc.date.available2018-03-29T05:52:20Z
dc.identifierMenopause-the Journal Of The North Amrerican Menopause Society. Lippincott Williams & Wilkins, v. 23, p. 792 - 798, 2016.
dc.identifier1072-3714
dc.identifier1530-0374
dc.identifierWOS:000379370600014
dc.identifier10.1097/GME.0000000000000613
dc.identifierhttps://insights.ovid.com/pubmed?pmid=27116462
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/327209
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1364234
dc.descriptionVaginal atrophy is a common chronic condition among postmenopausal women that can affect their quality of life. Recent studies have evaluated new treatment alternatives for vaginal atrophy; however, few therapeutic options have been thoroughly evaluated. This study aimed to compare the effectiveness and adverse effects of estrogen, testosterone, polyacrylic acid, and placebo lubricant for the treatment of postmenopausal women with vaginal atrophy. Methods: We conducted a randomized clinical trial with 80 postmenopausal women aged between 40 and 70 years who were being followed up at the Menopause Clinic of CAISM UNICAMP between November 2011 and January 2013. Women were randomly assigned to topical vaginal treatment with estrogen, testosterone, polyacrylic acid, and placebo lubricant, three times a week for 12 weeks. We used the vaginal maturation index, pH, vaginal health score, vaginal flora, laboratory tests, and ultrasound to evaluate changes of vaginal atrophy at baseline and after 6 and 12 weeks of treatment. Results: After a 12-week treatment with topical estrogen and testosterone compared with the lubricant, an increased percentage of participants had vaginal pH less than 5, increased vaginal score, and an increase in the number of lactobacilli. Treatment with topical estrogen improved the vaginal maturation index and showed increased levels of estradiol in three women. No changes were observed in the endometrial evaluation of all treatment groups. Conclusions: After a 12-week treatment with testosterone and estrogen compared with placebo lubrication, there was a significant improvement in vaginal trophism in postmenopausal women with vaginal atrophy.
dc.description23
dc.description7
dc.description792
dc.description798
dc.languageEnglish
dc.publisherLippincott Williams & Wilkins
dc.publisherPhiladelphia
dc.relationMenopause-The Journal of the North Amrerican Menopause Society
dc.rightsfechado
dc.sourceWOS
dc.subjectMenopause
dc.subjectTestosterone
dc.subjectVaginal Atrophy
dc.subjectEstrogen
dc.titleEfficacy Of Vaginally Applied Estrogen, Testosterone, Or Polyacrylic Acid On Vaginal Atrophy: A Randomized Controlled Trial
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución