The Endothelial Mineralocorticoid Receptor: Mediator Of The Switch From Vascular Health To Disease

dc.creatorDavel
dc.creatorAna P.; Anwar
dc.creatorImran J.; Jaffe
dc.creatorIris Z.
dc.date2017
dc.datemar
dc.date2017-11-13T13:14:26Z
dc.date2017-11-13T13:14:26Z
dc.date.accessioned2018-03-29T05:52:12Z
dc.date.available2018-03-29T05:52:12Z
dc.identifierCurrent Opinion In Nephrology And Hypertension. Lippincott Williams & Wilkins, v. 26, p. 97 - 104, 2017.
dc.identifier1062-4821
dc.identifier1473-6543
dc.identifierWOS:000393964400005
dc.identifier10.1097/MNH.0000000000000306
dc.identifierhttps://insights.ovid.com/pubmed?pmid=27930384
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/327176
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1364201
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionPurpose of review Endothelial dysfunction is an early feature of vascular disease induced by cardiovascular risk factors (CRFs). In growing populations with obesity, diabetes, hypertension, and heart failure, mineralocorticoid receptor antagonism improves endothelial function. This review summarizes recent advances in our understanding of the specific role of endothelial cell mineralocorticoid receptor in vascular function in health and disease. Recent findings Using transgenic mice with mineralocorticoid receptor expression specifically modulated in endothelial cells, recent studies support the emerging concept that while endothelial cell mineralocorticoid receptor may be protective in health, in the presence of CRFs, endothelial cell mineralocorticoid receptor activity contributes to endothelial dysfunction and progression of vascular disease. Proposed mechanisms include a role for endothelial cell mineralocorticoid receptor in decreased nitric oxide production and bioavailability, increased vascular oxidative stress, regulation of epithelial sodium channels that enhance vascular stiffness, and increased endothelial cell adhesion molecules promoting inflammation. The role of endothelial cell mineralocorticoid receptor may also depend on the sex, race, or vascular bed involved. Summary Recent advances support the idea that endothelial cell mineralocorticoid receptor is a mediator of the switch from vascular health to disease in response to CRFs. Further investigation of the molecular mechanism is underway to identify therapeutic interventions that will limit the detrimental effects of endothelial cell mineralocorticoid receptor in patients at cardiovascular risk.
dc.description26
dc.description2
dc.description97
dc.description104
dc.descriptionNational Institute of Health [HL095590]
dc.descriptionAmerican Heart Association [EIA 18290005]
dc.descriptionSao Paulo Research Foundation [FAPESP 14/26192-6]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageEnglish
dc.publisherLippincott Williams & Wilkins
dc.publisherPhiladelphia
dc.relationCurrent Opinion in Nephrology and Hypertension
dc.rightsfechado
dc.sourceWOS
dc.subjectCardiovascular Disease
dc.subjectEndothelial Function
dc.subjectMineralocorticoid Receptor
dc.titleThe Endothelial Mineralocorticoid Receptor: Mediator Of The Switch From Vascular Health To Disease
dc.typeArtículos de revistas


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