Effects Of Low Level Laser Therapy On Inflammatory And Angiogenic Gene Expression During The Process Of Bone Healing: A Microarray Analysis

dc.creatorTim
dc.creatorCarla Roberta; Bossini
dc.creatorPaulo Sergio; Kido
dc.creatorHueliton Wilian; Malavazi
dc.creatorIran; von Zeska Kress
dc.creatorMarcia Regina; Carazzolle
dc.creatorMarcelo Falsarella; Parizotto
dc.creatorNivaldo Antonio; Renno
dc.creatorAna Claudia
dc.date2016
dc.datejan
dc.date2017-11-13T13:13:20Z
dc.date2017-11-13T13:13:20Z
dc.date.accessioned2018-03-29T05:51:20Z
dc.date.available2018-03-29T05:51:20Z
dc.identifierJournal Of Photochemistry And Photobiology And B-biology. Elsevier Science Sa, v. 154, p. 8 - 15, 2016.
dc.identifier1011-1344
dc.identifierWOS:000368954300002
dc.identifier10.1016/j.jphotobiol.2015.10.028
dc.identifierhttp://www-sciencedirect-com.ez88.periodicos.capes.gov.br/science/article/pii/S1011134415003577?via%3Dihub
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/327031
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1364056
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionThe process of bone healing as well as the expression of inflammatory and angiogenic genes after low level laser therapy (LLLT) were investigated in an experimental model of bone defects. Sixty Wistar rats were distributed into control group and laser group (830 nm, 30 mW, 2,8 J, 94 seg). Histopathological analysis showed that LLLT was able to modulate the inflammatory process in the area of the bone defect and also to produce an earlier deposition of granulation tissue and newly formed bone tissue. Microarray analysis demonstrated that LLLT produced an up-regulation of the genes related to the inflammatory process (MMD, PTGIR, PTGS2, Ptger2, ILL 1IL6, IL8, IL18) and the angiogenic genes (FGF14, FGF2, ANGPT2, ANGPT4 and PDGFD) at 36 h and 3 days, followed by the decrease of the gene expression on day 7. Immunohistochemical analysis revealed that the subjects that were treated presented a higher expression of COX-2 at 36 h after surgery and an increased VEGF expression on days 3 and 7 after surgery. Our findings indicate that LLLT was efficient on accelerating the development of newly formed bone probably by modulating the inflammatory and angiogenic gene expression as well as COX2 and VEGF immunoexpression during the initial phase of bone healing. (C) 2015 Elsevier B.V. All rights reserved.
dc.description154
dc.description8
dc.description15
dc.descriptionFAPESP [2010/15335-0]
dc.descriptionCenter for Computational Engineering and Sciences at UNICAMP SP Brazil (FAPESP/CEPID) [2013/08293-7]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageEnglish
dc.publisherElsevier Science SA
dc.publisherLausanne
dc.relationJournal of Photochemistry and Photobiology and B-Biology
dc.rightsfechado
dc.sourceWOS
dc.subjectBone Repair
dc.subjectLllt
dc.subjectMicroarray
dc.subjectGene Expression
dc.titleEffects Of Low Level Laser Therapy On Inflammatory And Angiogenic Gene Expression During The Process Of Bone Healing: A Microarray Analysis
dc.typeArtículos de revistas


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