Tcf7l2 Rs7903146 Polymorphism Is Associated With Gastric Cancer: A Case-control Study In The Venezuelan Population

dc.creatorTorres
dc.creatorKeila; Labrador
dc.creatorLuis; Valderrama
dc.creatorElvis; Chiurillo
dc.creatorMiguel Angel
dc.date2016
dc.datejul
dc.date2017-11-13T13:13:18Z
dc.date2017-11-13T13:13:18Z
dc.date.accessioned2018-03-29T05:51:17Z
dc.date.available2018-03-29T05:51:17Z
dc.identifierWorld Journal Of Gastroenterology. Baishideng Publishing Group Inc, v. 22, p. 6520 - 6526, 2016.
dc.identifier1007-9327
dc.identifier2219-2840
dc.identifierWOS:000380769800017
dc.identifier10.3748/wjg.v22.i28.6520
dc.identifierhttps://www.wjgnet.com/1007-9327/full/v22/i28/6520.htm
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/327025
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1364050
dc.descriptionTo explore the association between TCF7L2 rs12255372 and rs7903146 single nucleotide polymorphisms (SNPs) and gastric cancer risk in Venezuelan patients. METHODS: We performed a case-control study including 122 paraffin-embedded archived intestinaltype gastric cancer samples and 129 biopsies obtained by superior endoscopy from chronic gastritis patients. Gastric cancer samples were classified according the degree of carcinoma differentiation. Genomic DNA was extracted from tissues, and the two SNPs of TCF7L2 gene (rs12255372 and rs7903146) were genotyped by polymerase chain reaction-restriction fragment length polymorphism reactions. Multiple regression analysis with adjustments for age and gender were performed and best-fitting models of inheritance were determined. RESULTS: After adjusting for age and sex the TCF7L2 rs7903146 TT genotype was associated with gastric cancer risk under the recessive genetic model (OR = 3.11, 95% CI: 1.22-7.92, p = 0.017). We further investigated the distribution of rs12255372 and rs7903146 genotypes according gastric cancer stratified by degree of differentiation, and we observed that carriers of rs7903146 T allele (CT + TT vs CC) had a significantly increased risk of moderate/well differentiated gastric cancer (dominant model, OR = 2.55, 95% CI: 1.35-4.80, p = 0.004), whereas the rs7903146 TT genotype was associated with poorly differentiated gastric cancer in the recessive model (OR = 3.65, 95% CI: 1.25-10.62, p = 0.018). We did not find association between rs12255372 SNP and the susceptibility of developing gastric cancer. CONCLUSION: TCF7L2 rs7903146 polymorphism is associated with gastric cancer risk in the Venezuelan population, and could be related to determine the degree of differentiation of tumor cells.
dc.description22
dc.description28
dc.description6520
dc.description6526
dc.descriptionCDCHT-UCLA grant [001-CS-2013]
dc.languageEnglish
dc.publisherBaishideng Publishing Group Inc
dc.publisherPleasanton
dc.relationWorld Journal of Gastroenterology
dc.rightsaberto
dc.sourceWOS
dc.subjectGastric Cancer
dc.subjectWnt/beta-catenin Pathway
dc.subjectTcf7l2
dc.subjectSingle Nucleotide Polymorphism
dc.subjectGenetic Susceptibility
dc.titleTcf7l2 Rs7903146 Polymorphism Is Associated With Gastric Cancer: A Case-control Study In The Venezuelan Population
dc.typeArtículos de revistas


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