Functional Effects Of Milk Bioactive Peptides On Skeletal Muscle Of Rats

dc.creatorMoura
dc.creatorCarolina Soares; Barboza Lollo
dc.creatorPablo Christiano; Morato
dc.creatorPriscila Neder; Risso
dc.creatorEder Muller; Amaya-Farfan
dc.creatorJaime
dc.date2016
dc.datejun
dc.date2017-11-13T13:12:57Z
dc.date2017-11-13T13:12:57Z
dc.date.accessioned2018-03-29T05:51:03Z
dc.date.available2018-03-29T05:51:03Z
dc.identifierFood Research International. Elsevier Science Bv, v. 84, p. 18 - 25, 2016.
dc.identifier0963-9969
dc.identifier1873-7145
dc.identifierWOS:000376698900003
dc.identifier10.1016/j.foodres.2016.03.001
dc.identifierhttp://www-sciencedirect-com.ez88.periodicos.capes.gov.br/science/article/pii/S0963996916300679?via%3Dihub
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/326967
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1363992
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionWhey protein hydrolysate (WPH) intake has shown to enhance heat shock proteins (HSPs). The presence of bioactive peptides has been suggested to affect the capacity of WPH to induce a HSP response. HSPs are responsible for maintaining normal cellular function and protecting cells from the damage induced by various stressors, including exercise. Bioactive peptides have been considered as food components that could be biofunctionality, however, studies focusing on potential bioactive peptides from WPH are still limited. The purpose of this study was to determine which WPH peptides could modulate the HSP response and other WPH abilities. Fifty-six male Wistar rats were divided into seven groups (n = 8): control, vehicle, Isoleucyl-leucine (lle-Leu), Leucyl-isoleucine (Leu-lle), Valyl-leucine (Val-Leu), Leucyl-valine (Leu-Val) and WPH. Each animal received 3 mmol/kg dose of peptide or WPH dissolved in water by oral gavage. Except for the control group, all groups were subjected to acute exercise for homeostasis alteration. Treadmill exercise has been established as a stimulus for an HSP response. The Leu-Val peptide increased the HSP70 and HSP25 muscle expression and restored the dihydrofolate reductase (DHFR) expression. lle-Leu increased the muscle and serum HSP70 levels, but did not change the HSP25. Leu-Val increased and restored the expression of antioxidant system components. All peptides enhanced the lipase expression and reduced the cholesterol and triacylglycerol levels. These results indicated that the Leu-Val peptide is most likely involved in the WPH-induced stimulation of the HSP upregulation and antioxidant response, including the protective mechanism (DHFR) associated with the HSP70 effect Additionally, the lle-Leu could also contribute to the WPH effect. (C) 2016 Elsevier Ltd. All rights reserved.
dc.description84
dc.description18
dc.description25
dc.descriptionFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil (Sao Paulo Research Foundation, FAPESP) [2013/02862-0, 2013/06494-5]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageEnglish
dc.publisherElsevier Science BV
dc.publisherAmsterdam
dc.relationFood Research International
dc.rightsfechado
dc.sourceWOS
dc.subjectChaperones
dc.subjectBioactive Peptide
dc.subjectProtection
dc.subjectStress
dc.subjectWhey
dc.subjectSurvival
dc.titleFunctional Effects Of Milk Bioactive Peptides On Skeletal Muscle Of Rats
dc.typeArtículos de revistas


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