Abnormality In Hippocampal Signal Intensity Predicts Atrophy In Patients With Systemic Lupus Erythematosus

dc.creatorLapa
dc.creatorA. T.; Pedro
dc.creatorT.; Francischinelli
dc.creatorJ.; Coan
dc.creatorA. C.; Lavras Costallat
dc.creatorL. T.; Cendes
dc.creatorF.; Appenzeller
dc.creatorS.
dc.date2017
dc.datemaio
dc.date2017-11-13T13:12:40Z
dc.date2017-11-13T13:12:40Z
dc.date.accessioned2018-03-29T05:50:51Z
dc.date.available2018-03-29T05:50:51Z
dc.identifierLupus. Sage Publications Ltd, v. 26, p. 633 - 639, 2017.
dc.identifier0961-2033
dc.identifier1477-0962
dc.identifierWOS:000399305000009
dc.identifier10.1177/0961203316673151
dc.identifierhttp://journals.sagepub.com/doi/abs/10.1177/0961203316673151
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/326925
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1363950
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionTo quantify signal abnormalities in the hippocampus (Hsig) of patients with systemic lupus erythematosus (SLE) and to determine if Hsig predict hippocampal atrophy (HA) in SLE. Methods We included all SLE patients and healthy age- and sex-matched individuals with two magnetic resonance imaging (MRI) scans performed with a minimum of 1 year interval. All individuals underwent a standardized neuropsychological evaluation. Individual results were converted into standard scores and compared to normative data. SLE patients were additionally assessed for disease activity (SLE Disease Activity Index (SLEDAI)), damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI)), and the presence of antiphospholipid antibodies. MRI was performed on an Elscint 2 T scanner and T1 inversion recovery and T2 coronal images were used for analysis. Volumetric (HV) and signal quantification (Hsig) were determined by standardized protocols. Results We included 54 SLE patients (48 women; mean age 32.210.56 years). Hsig were found at study entry in 15 (45.5%) patients. Hsig in the body and tail of non-atrophic hippocampi correlated with progression of volume loss during the follow-up period (r=0.8, p<0.001). The presence of Hsig in the head of atrophic hippocampi correlated with progression of HA (r=0.73, p=0.005) during the same period. No correlation of Hsig and disease activity or prednisone dose was observed. Conclusion HA is frequently observed in SLE patients and volume loss is progressive in a subgroup of patients. The evaluation of Hsig is an easy tool to determine patients that may have progressive hippocampal volume loss and should be followed more closely with MRI and cognitive evaluation.
dc.description26
dc.description6
dc.description633
dc.description639
dc.descriptionFundacao Amparo A Pesquisa Estado Sao Paulo-Brasil [FAPESP 2008/02917-0, 2009/06049-6, 2009/11076-2, 2013/07559-3]
dc.descriptionConselho Nacional Pesquisa Desenvolvimento-Brasil CNPq [300447/2009-4, 471343/2011-0, 302205/2012-8, 473328/2013-5, 157534/2015-4]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageEnglish
dc.publisherSage Publications LTD
dc.publisherLondon
dc.relationLupus
dc.rightsfechado
dc.sourceWOS
dc.subjectHippocampal Signal Abnormality
dc.subjectGliosis
dc.subjectCognitive Impairment
dc.titleAbnormality In Hippocampal Signal Intensity Predicts Atrophy In Patients With Systemic Lupus Erythematosus
dc.typeArtículos de revistas


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