Artículos de revistas
Biliopancreatic Diversion Decreases Postprandial Apolipoprotein A-iv Levels In Mildly Obese Individuals With Type 2 Diabetes Mellitus: A Prospective Study
Registro en:
Obesity Surgery. Springer, v. 27, p. 1008 - 1012, 2017.
0960-8923
1708-0428
WOS:000398070900024
10.1007/s11695-016-2414-7
Autor
Cazzo
Everton; Pareja
Jose Carlos; Geloneze
Bruno; Chaim
Elinton Adami; Lazzarini Barreto
Maria Rita; Magro
Daniela Oliveira
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Bariatric surgery usually leads to improvement on the general lipid profile, but its role in the levels of apolipoprotein A-IV (Apo-AIV) is not completely understood. Apo-AIV is a gut-released lipoprotein which is enrolled in satiety regulation and presents anti-inflammatory, anti-atherogenic, and anti-oxidative properties. The objective of this study was to determine the influence of biliopancreatic diversion (BPD) in the levels of Apo-AIV. Methods This is a prospective exploratory study which evaluated eight obese individuals with type 2 diabetes mellitus (T2DM) who underwent BPD (Scopinaro operation) and were followed-up for 12 months. Apo-AIV levels were determined by means of serial dosages through a standard meal tolerance test (MTT) in the immediate preoperative period and then 12 months later. Results There was a significant change in the Apo-AIV curve following MTT before and after surgery. At 0 and 45 min, the Apo-AIV levels did not significantly differ before and after surgery; at 120 and 180 min, Apo-AIV levels were significantly lower following BPD. Conclusions We observed a decrease of postprandial levels of Apo-AIV following MTT in mildly obese individuals with T2DM. This finding appears to be related to the suppression in the Apo-AIV response that obese individuals tend to present. Weight reduction itself, endotoxemia, and the large segments of bypassed intestine may be enrolled in this impaired response. 27 4 1008 1012 Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESP [2009/50430-6] Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)