Rhce Variants Inherited With Altered Rhd Alleles In Brazilian Blood Donors

dc.creatorPrisco Arnoni
dc.creatorC.; Guilhem Muniz
dc.creatorJ.; de Paula Vendrame
dc.creatorT. A.; de Medeiros Person
dc.creatorR.; Roche Moreira Latini
dc.creatorF.; Castilho
dc.creatorL.
dc.date2016
dc.dateagos
dc.date2017-11-13T13:12:22Z
dc.date2017-11-13T13:12:22Z
dc.date.accessioned2018-03-29T05:50:36Z
dc.date.available2018-03-29T05:50:36Z
dc.identifierTransfusion Medicine. Wiley-blackwell, v. 26, p. 285 - 290, 2016.
dc.identifier0958-7578
dc.identifier1365-3148
dc.identifierWOS:000384665900006
dc.identifier10.1111/tme.12309
dc.identifierhttp://onlinelibrary-wiley-com.ez88.periodicos.capes.gov.br/doi/10.1111/tme.12309/abstract?systemMessage=Wiley+Online+Library+will+be+unavailable+on+Saturday+12th+August+at+3%3A00+EDT+%2F+8%3A00+BST+%2F+12%3A30+IST+%2F+15%3A00+SGT+for+4+hours+for+essential+maintenance.+Apologies+for+the+inconvenience.
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/326859
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1363884
dc.descriptionThe high homology and opposite orientation of RH genes promote rearrangements between them and generate a large number of RHD and RHCE variants which can be inherited together. Searching of RHD-CE genotypes predicting partial antigens in donors is of interest in order to find more closely matched donors for African descent patients. This study aimed to evaluate a molecular approach to search for RhCE variants in a cohort of individuals with altered expression of D antigen and determine the association of RH variant alleles in Brazilian blood donors. METHODSFrom 80,961 blood samples tested, 421 with atypical D typing results were studied. The samples were phenotyped for C, c, E, e antigens. Rh variants were identified using molecular techniques. RESULTSAll 421 samples had altered RHD alleles, being 563% of them partial D. Among them, 949% presented variant RHCE*ce and the most common associations were: RHD*weak D type 4.2.2 with RHCE*ceAR; RHD*DAR linked to RHCE*ceVS.02; RHD*weak D type 4.0 linked to RHCE*ceVS.02 and RHCE*ce (c.48C, c.105T, c.733G, c.744C, c.1025T). Among the samples with RhCE variants, 106% predict partial c, partial e, hr(B)- and/or hr(S)- and 100% express low prevalence antigens. CONCLUSIONTargeting individuals with altered expression of D antigen can be a good strategy for finding donors with RhCE variants. In our study 949% of the partial D samples revealed altered RHCE variant alleles and 57% of the samples with altered RHD allele predicted partial c, partial e and the lack of the high prevalence hr(B)and hr(S)antigens.
dc.description26
dc.description4
dc.description285
dc.description290
dc.languageEnglish
dc.publisherWiley-Blackwell
dc.publisherHonoken
dc.relationTransfusion Medicine
dc.rightsfechado
dc.sourceWOS
dc.subjectBlood Group Genotyping
dc.subjectPartial Rhd
dc.subjectRh Variants
dc.subjectRhce Alleles
dc.titleRhce Variants Inherited With Altered Rhd Alleles In Brazilian Blood Donors
dc.typeArtículos de revistas


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