dc.creatorStiz
dc.creatorDorimar; Campos
dc.creatorAdriana; Tasca Gois Ruiz
dc.creatorAna Lucia; de Carvalho
dc.creatorJoao Ernesto; Correa
dc.creatorRogerio; Cechinel-Filho
dc.creatorValdir
dc.date2016
dc.datenov
dc.date2017-11-13T13:11:50Z
dc.date2017-11-13T13:11:50Z
dc.date.accessioned2018-03-29T05:50:07Z
dc.date.available2018-03-29T05:50:07Z
dc.identifierZeitschrift Für Naturforschung C - A Journal Of Biosciences. Walter De Gruyter Gmbh, v. 71, p. 423 - 427, 2016.
dc.identifier0939-5075
dc.identifier1865-7125
dc.identifierWOS:000386937900009
dc.identifier10.1515/znc-2016-0067
dc.identifierhttps://www.degruyter.com/view/j/znc.2016.71.issue-11-12/znc-2016-0067/znc-2016-0067.xml
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/326746
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1363771
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThis work describes the antiproliferative potential of 14 cyclic imides (methylphtalimides, carboxylic acid phtalimides and itaconimides) against several human cancer cell lines. The antiproliferative effect was evaluated using the sulforhodamine B assay. Although some compounds from methylphtalimide and carboxylic acid phtalimide classes exhibited a selective antiproliferative activity, the itaconimides (11-14) exhibited the best results, especially compound 14, which presented a TGI (concentration that produces total growth inhibition) value of 0.0043 mu M against glioma (U251), being inactive against the non-tumor cell line (HaCat). Absorption, distribution, metabolism and excretion in silico evaluations suggest that these compounds are promising candidates.
dc.description71
dc.description423
dc.description427
dc.descriptionNational Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq)
dc.descriptionFundo de Apoio a Manutencao e ao Desenvolvimento da Educacao Superior - FUMDES (State of Santa Catarina)
dc.descriptionRIBECANCER/CYTED/CNPq Network [RT 0464]
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageEnglish
dc.publisherWalter De Gruyter GMBH
dc.publisherBerlin
dc.relationZeitschrift für Naturforschung C - A Journal of Biosciences
dc.rightsfechado
dc.sourceWOS
dc.subjectAdme
dc.subjectAntiproliferative Effect
dc.subjectCyclic Imides
dc.subjectItaconimides
dc.titleAntiproliferative Effect Of Synthetic Cyclic Imides (methylphtalimides, Carboxylic Acid Phtalimides And Itaconimides) Against Human Cancer Cell Lines
dc.typeArtículos de revistas


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