dc.creator | Stiz | |
dc.creator | Dorimar; Campos | |
dc.creator | Adriana; Tasca Gois Ruiz | |
dc.creator | Ana Lucia; de Carvalho | |
dc.creator | Joao Ernesto; Correa | |
dc.creator | Rogerio; Cechinel-Filho | |
dc.creator | Valdir | |
dc.date | 2016 | |
dc.date | nov | |
dc.date | 2017-11-13T13:11:50Z | |
dc.date | 2017-11-13T13:11:50Z | |
dc.date.accessioned | 2018-03-29T05:50:07Z | |
dc.date.available | 2018-03-29T05:50:07Z | |
dc.identifier | Zeitschrift Für Naturforschung C - A Journal Of Biosciences. Walter De Gruyter Gmbh, v. 71, p. 423 - 427, 2016. | |
dc.identifier | 0939-5075 | |
dc.identifier | 1865-7125 | |
dc.identifier | WOS:000386937900009 | |
dc.identifier | 10.1515/znc-2016-0067 | |
dc.identifier | https://www.degruyter.com/view/j/znc.2016.71.issue-11-12/znc-2016-0067/znc-2016-0067.xml | |
dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/326746 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1363771 | |
dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description | This work describes the antiproliferative potential of 14 cyclic imides (methylphtalimides, carboxylic acid phtalimides and itaconimides) against several human cancer cell lines. The antiproliferative effect was evaluated using the sulforhodamine B assay. Although some compounds from methylphtalimide and carboxylic acid phtalimide classes exhibited a selective antiproliferative activity, the itaconimides (11-14) exhibited the best results, especially compound 14, which presented a TGI (concentration that produces total growth inhibition) value of 0.0043 mu M against glioma (U251), being inactive against the non-tumor cell line (HaCat). Absorption, distribution, metabolism and excretion in silico evaluations suggest that these compounds are promising candidates. | |
dc.description | 71 | |
dc.description | 423 | |
dc.description | 427 | |
dc.description | National Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq) | |
dc.description | Fundo de Apoio a Manutencao e ao Desenvolvimento da Educacao Superior - FUMDES (State of Santa Catarina) | |
dc.description | RIBECANCER/CYTED/CNPq Network [RT 0464] | |
dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.language | English | |
dc.publisher | Walter De Gruyter GMBH | |
dc.publisher | Berlin | |
dc.relation | Zeitschrift für Naturforschung C - A Journal of Biosciences | |
dc.rights | fechado | |
dc.source | WOS | |
dc.subject | Adme | |
dc.subject | Antiproliferative Effect | |
dc.subject | Cyclic Imides | |
dc.subject | Itaconimides | |
dc.title | Antiproliferative Effect Of Synthetic Cyclic Imides (methylphtalimides, Carboxylic Acid Phtalimides And Itaconimides) Against Human Cancer Cell Lines | |
dc.type | Artículos de revistas | |