Cerebral Vasomotor Reactivity Assessment Using Transcranial Doppler And Mri With Apnea Test

dc.creatorCampos Herrera
dc.creatorC. R.; Beltramini
dc.creatorG. C.; Avelar
dc.creatorW. M.; Lima
dc.creatorF. O.; Li
dc.creatorL. M.
dc.date2016
dc.date2017-11-13T11:35:25Z
dc.date2017-11-13T11:35:25Z
dc.date.accessioned2018-03-29T05:49:33Z
dc.date.available2018-03-29T05:49:33Z
dc.identifierBrazilian Journal Of Medical And Biological Research. Assoc Bras Divulg Cientifica, v. 49, p. , 2016.
dc.identifier0100-879X
dc.identifier1678-4510
dc.identifierWOS:000386127000003
dc.identifier10.1590/1414-431X20165437
dc.identifierhttp://www.scielo.br/scielo.php?pid=S0100-879X2016001100704&script=sci_arttext
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/326629
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1363635
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionDifferently from previous studies that used Transcranial Doppler (TCD) and functional MRI (fMRI) for cerebral vasomotor reactivity (CVR) assessment in patients with carotid stenosis (CS), we assessed CVR using an identical stimulus, the Breath-Holding Test (BHT). We included 15 patients with CS and 7 age-matched controls to verify whether fMRI responded differently to BHT between groups and to calculate the agreement rate between tests. For TCD, impaired CVR was defined when the mean percentage increase on middle cerebral artery velocities was p31% on 3 consecutive 30-s apnea intercalated by 4-min normal breathing intervals. For fMRI, the percent variation on blood oxygen level-dependent (BOLD) signal intensity in the lentiform nucleus (LN) ipsilateral to the CS (or both LNs for controls) from baseline breathing to apnea was measured. The Euclidian differences between the series of each subject and the series of controls and patients classified it into normal or impaired CVR. We found different percent variations on BOLD-signal intensities between groups (P=0.032). The agreement was good in Controls (85.7%; kappa=0.69) and overall (77.3%; kappa=0.54). We conclude that BHT was feasible for CVR assessment on fMRI and elicited different BOLD responses in patients and controls, with a good overall agreement between the tests.
dc.description49
dc.description11
dc.descriptionFAPESP [2010/52027-1, 2013/07559-3]
dc.descriptionCNPq [480976/2010-4]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageEnglish
dc.publisherAssoc Bras Divulg Cientifica
dc.publisherSão Paulo
dc.relationBrazilian Journal of Medical and Biological Research
dc.rightsaberto
dc.sourceWOS
dc.subjectBlood Oxygen Level Dependence
dc.subjectTranscranial Doppler
dc.subjectCarotid Stenosis
dc.titleCerebral Vasomotor Reactivity Assessment Using Transcranial Doppler And Mri With Apnea Test
dc.typeArtículos de revistas


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