Effect Of Selective Beta-adrenoceptor Blockade And Surgical Resection Of The Celiac-superior Mesenteric Ganglion Complex On Delayed Liquid Gastric Emptying Induced By Dipyrone, 4-aminoantipyrine, And Antipyrine In Rats

dc.creatorVinagre
dc.creatorA. M.; Collares
dc.creatorE. F.
dc.date2016
dc.datemar
dc.date2017-11-13T11:35:24Z
dc.date2017-11-13T11:35:24Z
dc.date.accessioned2018-03-29T05:49:31Z
dc.date.available2018-03-29T05:49:31Z
dc.identifierBrazilian Journal Of Medical And Biological Research. Assoc Bras Divulg Cientifica, v. 49, p. , 2016.
dc.identifier0100-879X
dc.identifier1678-4510
dc.identifierWOS:000370521400007
dc.identifier10.1590/1414-431X20155011
dc.identifierhttp://www.scielo.br/scielo.php?pid=S0100-879X2016000300603&script=sci_arttext
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/326624
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1363630
dc.descriptionThere is evidence for participation of peripheral beta-adrenoceptors in delayed liquid gastric emptying (GE) induced in rats by dipyrone (Dp), 4-aminoantipyrine (AA), and antipyrine (At). The present study aimed to determine whether beta-adrenoceptors are involved in delayed GE induced by phenylpyrazole derivatives and the role of the prevertebral sympathetic nervous system in this condition. Male Wistar rats weighing 220-280 g were used in the study. In the first experiment rats were intravenously pretreated with vehicle (V), atenolol 30 mg/kg (ATE, beta(1)-adrenergic antagonist), or butoxamine 25 mg/kg (BUT, beta(2)-adrenergic antagonist). In the second experiment, rats were pretreated with V or SR59230A 2 mg/kg (SRA, beta(3)-adrenergic antagonist). In the third experiment, rats were subjected to surgical resection of the celiac-superior mesenteric ganglion complex or to sham surgery. The groups were intravenously treated with saline (S), 240 mu mol/kg Dp, AA, or At, 15 min after pretreatment with the antagonists or V and nine days after surgery. GE was determined 10 min later by measuring the percentage of gastric retention (% GR) of saline labeled with phenol red 10 min after gavage. The % GR (means +/- SE, n= 6) values indicated that BUT abolished the effect of Dp (BUT+Dp vs V+Dp: 35.0%+/- 5.1% vs 56.4%+/- 2.7%) and At (BUT+At vs V+At: 33.5%+/- 4.7% vs 52.9%+/- 2.6%) on GE, and significantly reduced (P<0.05) the effect of AA (BUT+AA vs V+AA: 48.0%+/- 5.0% vs 65.2%+/- 3.8%). ATE, SRA, and sympathectomy did not modify the effects of treatments. These results suggest that beta(2)-adrenoceptor activation occurred in delayed liquid gastric emptying induced by the phenylpyrazole derivatives dipyrone, 4-aminoantipyrine, and antipyrine. Additionally, the released neurotransmitter did not originate in the celiac-superior mesenteric ganglion complex.
dc.description49
dc.description3
dc.descriptionFundo de Apoio ao Ensino, a Pesquisa e Extensao (FAEPEX), Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brasil
dc.languageEnglish
dc.publisherAssoc Bras Divulg Cientifica
dc.publisherSão Paulo
dc.relationBrazilian Journal of Medical and Biological Research
dc.rightsaberto
dc.sourceWOS
dc.subjectGastric Emptying
dc.subjectDipyrone
dc.subject4-aminoantipyrine
dc.subjectAntipyrine
dc.subjectBeta(2)-adrenoceptor
dc.subjectPrevertebral Sympathetic Ganglia
dc.titleEffect Of Selective Beta-adrenoceptor Blockade And Surgical Resection Of The Celiac-superior Mesenteric Ganglion Complex On Delayed Liquid Gastric Emptying Induced By Dipyrone, 4-aminoantipyrine, And Antipyrine In Rats
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución