Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)This study employed direct UV-ABC photolysis and the UV-ABC/H2O2 process to investigate the degradation of tolfenamic add (TA), a common anti-inflammatory drug used in both human and veterinary medicine. A 23 factorial design with added center point was used to evaluate the effect of three independent variables namely, H2O2 concentration ([H2O2]), TA concentration ([TA]), and experiment time (time) on TA degradation and H2O2 photolysis during UV-ABC/H2O2 treatment using a high-pressure mercury vapor lamp (photon flux of 2.6307 x 10(4) J s(-1)) as the UV irradiation source. The responses yielded similar values, revealing a linear behavior, with correlation coefficients R = 0.9968 and R-adj = 0.9921 for TA degradation and R = 0.9828 and Radj = 0.9570 for H2O2 photolysis. The most efficient combination of variables was [H2O2] = 255 mg L-1 and [TA] = 25 mg L-1, resulting in 100% TA degradation and 98.87%H2O2 photolysis by 90 min of treatment. Additionally, the second order kinetic constant of the reaction between TA and HO center dot was determined using a competitive kinetic model, employing 2,4-dichlorophenoxyacetic acid (2,4D) as the reference compound. The kinetic constant was 1.9 x 1010 1 s-1 in alkaline medium. TA degradation by direct photolysis generated quinone imines as by products, responsible for the formation of a dark red "internal filter" that increased the value of acute toxicity to Artemia saline. The UV-ABC/H2O2 process did not promote formation of quinone imines by 90 min of treatment and therefore did not increase acute toxicity values. Several by-products generated during TA degradation were identified and possible degradation pathways for the UV-ABC and UV-ABC/H2O2 processes were proposed. (C) 2016 Elsevier B.V. All rights reserved.573518531Brazilian funding agency Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Brazilian funding agency Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (Capes)Brazilian funding agency Fundacao de Apoio ao Desenvolvimento do Ensino, Ciencia e Tecnologia do Estado de Mato Grosso do Sul (Fundect)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)