Artículos de revistas
Relationship Between The Iga Antibody Response Against Streptococcus Mutans Gbpb And Severity Of Dental Caries In Childhood
Registro en:
Archives Of Oral Biology. Pergamon-elsevier Science Ltd , v. 67, p. 22 - 27, 2016.
0003-9969
1879-1506
WOS:000375508400004
10.1016/j.archoralbio.2016.03.006
Autor
Colombo
Natalia Helena; Pereira
Jesse Augusto; Rodrigues da Silva
Marjully Eduardo; Fonseca Ribas
Lais Fernanda; Parisotto
Thais Manzano; Mattos-Graner
Renata de Oliveira; Smith
Daniel J.; Duque
Cristiane
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Explore the associations between the severity of dental caries in childhood, mutans streptococci (MS) levels and IgA antibody response against Streptococcus mutans GbpB. Moreover, other caries-related etiological factors were also investigated. Design: 36-60 month-old children were grouped into Caries-Free (CF, n = 19), Early Childhood Caries (ECC, n = 17) and Severe Early Childhood Caries (S-ECC, n = 21). Data from socio-economic-cultural status, oral hygiene habits and dietary patterns were obtained from a questionnaire and a food-frequency diary filled out by parents. Saliva was collected from children for microbiological analysis and detection of salivary IgA antibody reactive with S. mutans GbpB in western blot. Results: S-ECC children had reduced family income compared to those with ECC and CF. There was difference between CF and caries groups (ECC and S-ECC) in MS counts. Positive correlations between salivary IgA antibody response against GbpB and MS counts were found when the entire population was evaluated. When children with high MS counts were compared, S-ECC group showed significantly lower IgA antibody levels to GbpB compared to CF group. This finding was not observed for the ECC group. Conclusions: This study suggests that children with S-ECC have reduced salivary IgA immune responses to S. mutans GbpB, potentially compromising their ability to modify MS infection and its cariogenic potential. Furthermore, a reduced family income and high levels of MS were also associated with S-ECC. (C) 2016 Elsevier Ltd. All rights reserved. 67 22 27 Sao Paulo Research Foundation (FAPESP), Sao Paulo, SP, Brazil [2012/19235-5, 2013/12167-7] Coordination for the Improvement of Higher Education Personnel (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)