Radiotherapy Changes Salivary Properties And Impacts Quality Of Life Of Children With Hodgkin Disease

dc.creatorMarangoni-Lopes
dc.creatorL.; Rodrigues
dc.creatorL. P.; Mendonca
dc.creatorR. H.; Nobre-dos Santos
dc.creatorM.
dc.date2016
dc.datedez
dc.date2017-11-13T11:34:26Z
dc.date2017-11-13T11:34:26Z
dc.date.accessioned2018-03-29T05:48:40Z
dc.date.available2018-03-29T05:48:40Z
dc.identifierArchives Of Oral Biology. Pergamon-elsevier Science Ltd , v. 72, p. 99 - 105, 2016.
dc.identifier0003-9969
dc.identifier1879-1506
dc.identifierWOS:000387835400014
dc.identifier10.1016/j.archoralbio.2016.08.023
dc.identifierhttp://www-sciencedirect-com.ez88.periodicos.capes.gov.br/science/article/pii/S0003996916302205
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/326419
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1363425
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionWe aimed to perform a longitudinal investigation of the effects of radiotherapy on salivary flow rate, pH, buffering capacity, and protein composition of saliva and on the quality of life of children with Hodgkin disease. Design: Ten children (6-16-year-old) with Hodgkin disease and 10 matched healthy children were investigated. Stimulated and non-stimulated saliva samples were collected at baseline, after 1080 and 2160 cGy of radiation, and 1, 2, and 3 months post-radiotherapy. The salivary flow rate was expressed as mL/min. Buffer capacity was determined by titration. Amylase activity, immunoglobulin A, mucin, and lactoferrin concentrations were determined by ELISA. Quality of life was assessed by Quality of Life Head and Neck module 35 questionnaire. Results: We found that radiotherapy caused hyposalivation at 1080 cGy and 1 month after radiotherapy and reduced buffering capacity at 2160 cGy. Mucin concentration and amylase activity in non-stimulated saliva increased 1 month after radiotherapy. Lactoferrin concentration increased during and after radiotherapy. Immunoglobulin A concentration increased at 1080 cGy, 1 and 2 months, for non stimulated saliva and at 2160 cGy and 1 month for stimulated saliva. Children reported more pain after radiotherapy and more xerostomia during radiotherapy. Conclusion: We concluded that the radiotherapy protocol affected the children's salivary properties and children's quality of life. (C) 2016 Elsevier Ltd. All rights reserved.
dc.description72
dc.description99
dc.description105
dc.descriptionSao Paulo Research Foundation (FAPESP) [2012/02858-0]
dc.descriptionFAPESP [2012/14699-3]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageEnglish
dc.publisherPergamon-Elsevier Science LTD
dc.publisherOxford
dc.relationArchives of Oral Biology
dc.rightsfechado
dc.sourceWOS
dc.subjectHodgkin Disease
dc.subjectXerostomia
dc.subjectRadiotherapy
dc.subjectQuality-of-life
dc.subjectSaliva
dc.titleRadiotherapy Changes Salivary Properties And Impacts Quality Of Life Of Children With Hodgkin Disease
dc.typeArtículos de revistas


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